Clowney (knee) has been ruled out for Sunday's game against the Colts, Adam Caplan of SiriusXM NFL Radio reports.
Clowney is set to miss a second consecutive game due to a knee injury, and he was a DNP in all three practices during Week 3 prep. Dominique Robinson and Sabastian Harsh will continue to operate in elevated roles behind starting defensive ends Will Anderson and Danielle Hunter for as long as Clowney is on the shelf.