The Texans placed Hughes (hip) on injured reserve Saturday, Aaron Wilson of KPRC 2 Houston reports.
Hughes went from limited in Wednesday's practice to a DNP on Thursday and Friday. He was already ruled out ahead of Sunday's game against the Bills, but the injury appears severe enough for the 2010 first-round pick to miss multiple weeks. Hughes will be forced to sit for at least four games, and the earliest he can return is Week 9 against the Jets on Oct. 31.