Mixon isn't in uniform for Saturday's preseason game against the Giants, Aaron Wilson of KPRC 2 Houston reports.
It sounds like coach DeMeco Ryans had a change of heart after saying Thursday that Mixon would play. Mixon missed the first two and a half weeks of training camp with a quad injury, but he returned to practice last weekend and still has three weeks to prepare for the start of the regular season. His absence Saturday leaves Dameon Pierce as the probable starter at RB.