Mixon (ankle) didn't participate in practice Thursday, Jonathan M. Alexander of the Houston Chronicle reports.
The same goes for top backup Dameon Pierce (hamstring), with both players also having been DNPs on Wednesday. As a result, the duo's status for Sunday's game against the Vikings is cloudy, and in the event that both Mixon and Pierce are unavailable this weekend, Cam Akers would be in line to step into an expanded role, according to Wilson.