Coach Mike Vrabel has ruled out Firkser (knee) for Sunday's game versus the Colts, Turron Davenport of ESPN.com reports.
Firkser didn't practice at all this week and now will miss his second consecutive contest since injuring his knee during the first session of Week 2 prep. He may have to return to the field in some capacity to put himself on a reasonable path to return to action. Until that happens, though, the Titans will rely on Geoff Swaim, MyCole Pruitt and Tommy Hudson at tight end.