The Titans placed Slater (foot) on their injured reserve list Tuesday, Jim Wyatt of the team's official site reports.
Slater sustained a serious foot injury during Sunday's game against the Giants, and his immediate backup, Fernando Carmona (ankle), was also hurt badly when he stepped into Slater's place. Both will have to miss at least Tennessee's next four games, potentially leaving free-agent acquisition Atonio Mafi or rookie sixth-rounder Pat Coogan as starting options at right guard.