Markstrom didn't come out for the second period of Monday's road matchup with Buffalo, stopping nine of 11 shots on net.
Markstrom was replaced by Akira Schmid, who would take the loss despite making 18 saves while conceding three goals. If the 36-year-old Markstrom doesn't have a serious injury, it's possible that he gets the nod for Tuesday's clash with the Blue Jackets since he only played one period.