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One Sweet 16 streak is guaranteed to end in the NCAA Tournament 2025, and the NCAA Selection Committee can be thanked for its upcoming demise. Gonzaga (nine) and Houston (five) have the two longest active streaks of Sweet 16 appearances, with one of those, at least, guaranteed to end in 2025 March Madness. That's because the two would meet in the Round of 32, provided they win their first-round matchups. No. 1 Houston faces NCAA Tournament newcomer SIU Edwardsville, while No. 8 Gonzaga takes on 9-seed Georgia.
No other school in the NCAA Tournament 2025 or otherwise has more than two straight Sweet 16 appearances. The Cougars and Zags have never faced off before in any setting, so this could be one of the must-see matchups of the opening weekend of March Madness. Before making any 2025 March Madness bracket predictions, be sure to check out the 2025 NCAA Tournament bracket picks from SportsLine's team of proven college basketball experts.
SportsLine has nine NCAA Tournament expert brackets from some of the top minds in the sport. These experts have a proven track record of nailing college basketball picks. They include Bruce Marshall, who is on a 77-41 roll on college basketball picks, as well as Matt Severance (67-33 run), Jason La Canfora (61-37 run) and Tom Casale (57-32 run). There's simply no reason to rely on chance when this level of college basketball expertise is available to help.
Now, with the 2025 NCAA bracket revealed, the experts have evaluated every matchups and the results are in. You can only see all the expert brackets over at SportsLine.
Top 2025 March Madness expert bracket picks
One of the most intriguing 2025 March Madness expert brackets belongs to Tom Casale, who enters the NCAA Tournament 2025 on a 59-32 roll on college basketball picks.
Casale has No. 11 seed VCU making a run to the Sweet 16 in the East Region. Casale predicts the Rams will upset No. 6 BYU in the first round before knocking off No. 3 Wisconsin to advance to the Sweet 16. Both BYU and Wisconsin are 3-point dependent teams, which plays to VCU's strength as the Rams are allowing the 15th-fewest made triples per game (5.9) this season. An 11 seed has made the Sweet 16 in four straight years and Casale believes VCU has the defense to make a deep run.
Another surprising pick from Casale in the East features No. 13 Akron knocking off No. 4 Arizona. The Wildcats reached the Big 12 Final before falling to Houston, who is a No. 1 seed in the Midwest Region, but Casale likes the Mid-American Championships to shock them early. Akron is 20-1 over its last 21 games as the Zips dominated MAC play this season and Casale expects the winning to carry into March Madness. You can see Casale's full bracket, along with eight other expert brackets, at SportsLine.
How to make 2025 NCAA bracket predictions
Four of SportsLine's experts agree on a national title winner, and one expert is pushing a double-digit longshot all the way to the Final Four. You'll want to see which stunners the experts are calling for before locking in any 2025 NCAA bracket picks.
So what is the most common NCAA Tournament championship pick among SportsLine experts, and which shocking double-digit seed ends up in the Final Four? Visit SportsLine now to see which teams you can back with confidence, all from a team of experts with a history of crushing college basketball picks.
