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The 2025 NCAA Tournament Sweet 16 tips on Thursday. Seven SEC teams are part of the 2025 March Madness Sweet 16, including Kentucky and Tennessee. The two longtime SEC rivals will face off with a trip to the Elite Eight on the line on Friday at 7:39 p.m. ET. The 2025 NCAA bracket only features one double-digit seed in the Sweet 16, as No. 10 seed Arkansas will face No. 3 seed Texas Tech on Thursday. Should your 2025 NCAA Tournament picks include backing the Razorbacks to continue their Cinderella run? Who should you back in pivotal March Madness Sweet 16 matchups like Duke vs. Arizona, Michigan vs. Auburn and Purdue vs. Houston? Before locking in any March Madness predictions, be sure to see the 2025 NCAA Tournament bracket picks from the proven computer model at SportsLine.

SportsLine's proven projection model has simulated every game in the tournament 10,000 times. It has absolutely crushed its March Madness picks recently, beating over 91% of all CBS Sports brackets in four of the past six tournaments. The model nailed 13 of the 16 teams in the Sweet 16, and all four of its Final Four teams are still in the field.  It knows how to spot an upset as well. The same model has produced brackets that have nailed 25 first-round upsets by double-digit seeds since its inception in 2016.

There's no reason to rely on luck when there's proven technology to help you dominate your 2025 March Madness picks. Now, with the remainder of the 2025 NCAA bracket revealed, the model is simulating the matchups and its results are in. You can only see it over at SportsLine.

Top 2025 NCAA Tournament Sweet 16 picks

One of the Sweet 16 picks from the model: No. 2 seed Tennessee, despite losing to Kentucky twice this season, beats the Wildcats on Friday. Tennessee has experience on its side after advancing to the Elite Eight in 2024, and the Volunteers feature a plethora of playmakers capable of taking over a game.

Senior point guard Zakai Zeigler is one of the best floor generals in college basketball and averages 7.4 assists per game, which ranks fifth in the nation. He's connecting on 41.3% of his field goals and scores 13.7 points per contest. In Tennessee's win over UCLA in the second round, Zeigler stuffed the stat sheet with 15 points, six assists, three rebounds and three steals. Zeigler and the Vols should find success against a Kentucky defense that is giving up 77.2 points per game this season, which ranks 308th in college basketball. You can see the model's 2025 NCAA bracket picks here.

How to make 2025 NCAA bracket predictions

SportsLine's model also says the Final Four will feature something that hasn't happened in almost 20 years. With the model's track record of calling bracket-busting upsets, you'll want to see which teams it's picking this year before locking in any 2025 NCAA bracket picks.

So what's the optimal NCAA Tournament 2025 bracket, and what historic Final Four does the model predict? Visit SportsLine now to see which teams you can back with confidence, all from the model that has called 25 first-round upsets by double-digit seeds and nailed 13 Sweet 16 teams this year.