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As the college basketball landscape changes in the NIL era, the Sweet 16 of the 2025 NCAA Tournament bracket features what could become a trend of larger, dominant programs. For the second straight year, there are no one-bid conferences in the March Madness Sweet 16 after having one the prior three NCAA Tournaments. Arkansas is the only double-digit seed to reach the second week of 2025 NCAA bracket, but as one of 14 SEC teams to make March Madness 2025, few would call it a shock that Arkansas made the Sweet 16.

Several of the largest programs in college athletics like Duke, Alabama, Florida, Kentucky and Michigan, have advanced to the 2025 NCAA Tournament Sweet 16. Before locking in any 2025 March Madness predictions, be sure to check out the 2025 NCAA bracket picks from SportsLine college basketball expert Thomas Casale.

A frequent guest on national radio and TV shows to discuss college sports, Casale has a knack for picking college basketball winners, going 341-208 (62.1%) over the last three campaigns. He joined SportsLine in 2024 and promptly went 28-14-1 (67%) in CBB, returning $1,215 to $100 players. He's now 60-36 (+1828) in his last 96 official college basketball plays on SportsLine.

There's simply no reason to rely on luck when there's a proven expert to help you dominate your 2025 March Madness picks. Now, Casale has analyzed the Sweet 16 teams and revealed his predictions for the remainder of the NCAA Tournament bracket 2025. You can only see his second-chance 2025 NCAA Tournament bracket over at SportsLine.

Top 2025 NCAA Tournament Sweet 16 bracket

One 2025 NCAA Tournament upset that Casale is calling in his second-chance March Madness brackets: No. 10 seed Arkansas to upset No. 3 seed Texas Tech in the West Region semifinals. The Razorbacks are the final hope of a No. 8 seed or lower reaching the Final Four for the fifth straight year and what makes this underdog possibly more appealing than those in the past is the commonality of the Razorbacks seeing elite talent. Arkansas played seven Sweet 16 teams this season.

The Razorbacks have only two wins against those seven Sweet 16 teams, but they've seen the best of the best. Arkansas was underdogs against both Kansas and St. John's during March Madness before reaching the Sweet 16 and with John Calipari as head coach, Arkansas will be prepared and confident. Arkansas defeated St. John's despite shooting just 2 of 19 on 3-pointers by holding St. John's to 28% from the field. That defensive success can bring the Razorbacks to the Elite Eight. See the rest of Casale's second-chance 2025 March Madness bracket here.

How to make 2025 NCAA Tournament bracket predictions

Casale has also predicted the rest of the 2025 March Madness bracket, including a No. 1 seed that goes down hard in the Elite Eight. With Casale's proven track record over the last three years in college basketball, you'll want to see the rest of his 2025 NCAA Tournament bracket picks at SportsLine.

Which teams should you back as you make college basketball picks and fill out your second-chance 2025 NCAA Tournament brackets? And which No. 1 goes down in flames? Visit SportsLine now to see which teams you can back with confidence, all from the expert on a 60-36 run on college hoops picks.