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The 2025 NCAA Tournament bracket is set. Top seeds Auburn, Duke, Florida and Houston all have the talent to run through the 2025 March Madness bracket, but plenty of dangerous bluebloods like No. 3 Kentucky, No. 7 Kansas and No. 11 North Carolina are lurking throughout the 2025 NCAA bracket as well. The 6 vs. 11 matchups could be popular 2025 NCAA Tournament upset picks given the recent success of higher-seeded teams. In fact, No. 11 seeds are 30-26 in the first round since 2010 and went 3-1 in 2024.

History virtually guarantees there will be 2025 March Madness bracket busters coming. Which 2025 NCAA Tournament Cinderella teams should you target, and which higher seeds have the best chance to cut down the nets in San Antonio on April 7? Before making any 2025 NCAA Tournament predictions, see the 2025 March Madness bracket picks from the proven computer model at SportsLine.

Their proven projection model has simulated every game in the tournament 10,000 times. It has absolutely crushed its March Madness picks recently, beating over 91% of all CBS Sports brackets in four of the past six tournaments. It was all over UConn's championship run a year ago and nailed 13 teams in the Sweet 16. It also nailed Alabama's Cinderella run to the Final Four as a 4-seed.

It knows how to spot an upset as well. The same model has produced brackets that have nailed 24 first-round upsets by double-digit seeds since its inception in 2016. There's simply no reason to rely on luck when there's proven technology to help you dominate your 2025 March Madness bracket picks. 

Now, SportsLine's advanced computer model has simulated the entire 2025 NCAA Tournament 10,000 times to come up with the perfect 2025 NCAA Tournament bracket and find out which teams will pull off the biggest upsets. You shouldn't even think about making a pick without seeing what their model has to say.

Three 2025 March Madness bracket games to watch

One of the most intriguing 2025 March Madness matchups to watch: No. 8 UConn vs. No. 9 Oklahoma in the West Region. The two-time defending national champion Huskies will have a challenging road toward a three-peat and that's largely due to their poor start this year. UConn opened the season 4-3 after losing four of their top-five scorers from the season before. This year, the Huskies have three players within 0.2 points of each other with the trio of Solo Ball, Liam McNeeley and Alex Karaban sharing the primary offensive responsibilities and making them a challenge to game plan against. Meanwhile, Oklahoma has a dynamic duo of freshman guard Jeremiah Fears and senior forward Jalon Moore averaging 17 and 16 points per game, respectively. The Sooners won three of their final four games in a challenging SEC.

Another 2025 NCAA Tournament matchup to keep an eye on is No. 7 Kansas vs. No. 10 Arkansas in the West Region. This matchup is the only first-round contest where both programs have previously won national championships, and both head coaches in Bill Self and John Calipari are already Hall of Famers. The Jayhawks have won 17 straight Round of 64 games, but this is also the worst seed for the Jayhawks since being a No. 8 in 2000. As for Coach Cal's squad, it is expected to get back second-leading scorer Boogie Fland (15.1 ppg), who's been out for two months, thus giving the Hogs a nine-man rotation where each of those players averages over 5.5 points.

Another 2025 March Madness game to watch out for: No. 5 Memphis will battle No. 12 seed Colorado State in the West Region. Memphis features a plethora of playmakers capable of taking over a game. Penny Hardaway's squad is led by guard PJ Haggerty, who's averaging 21.8 points per game, the third-most in the nation. However, the Tigers have struggled on the defensive side of the ball, ranking 217th in scoring defense (73.2). Colorado State, meanwhile, has won each of its last 10 games and is averaging 16.6 assists per game. The Rams are led by Nique Clifford, who has averaged 27.8 points per game over his past four contests. You can see the model's 2025 NCAA bracket picks here.

How to make 2025 NCAA Tournament bracket predictions

Who wins every tournament-defining matchup, and which teams will make surprising runs through the 2025 NCAA Tournament bracket? With the model's track record of calling bracket-busting upsets, you'll want to see which stunners it's calling this year before locking in any 2025 NCAA bracket picks.

So what's the optimal NCAA Tournament 2025 bracket? And which NCAA Tournament Cinderella teams will shock college basketball? Visit SportsLine now to see which double-digit seeds you can back with confidence, all from the model that called UConn's national title and nailed 13 Sweet 16 teams in 2024.