Indians starter Corey Kluber (0-3) gave up six runs (four earned) on 10 hits in 6 1/3 innings on Monday to take the loss against the Royals.
Kluber struck out five in the contest and notched his 500th for his career. Kluber reached the milestone in his 80th game with the Indians, the second fastest to do so in franchise history (Herb Score, 68 games).
"He's one of the best pitchers in the game, if not the best pitcher in the game," Royals third baseman Mike Moustakas, who went 4 for 5 in the game, said. "We came away with a win against a great pitcher."
Kluber, the 2014 American League Cy Young Award winner, will look for his first win of the season Saturday against the Blue Jays.