Lakers vs. Spurs odds, prediction, line, time: 2026 NBA picks for Jan. 7 from proven model

A Western Conference matchup on Wednesday's NBA schedule has the Los Angeles Lakers visiting the San Antonio Spurs. The Lakers (23-11) have won three in a row, including a 111-103 victory over New Orleans on Tuesday. San Antonio (25-11) has lost back-to-back outings, including a 106-105 defeat to Memphis on Tuesday. LeBron James (sciatica, foot) is listed as questionable, while Austin Reaves (calf) and Rui Hachimura (calf) are both out for Los Angels. San Antonio lists Victor Wembanyama (knee) as questionable, while Devin Vassell (adductor) is out. 

Tipoff is at 9:30 p.m. ET from Frost Bank Center in San Antonio. The teams have split their two meetings this season. San Antonio is a 7.5-point favorite in the latest Lakers vs. Spurs odds per SportsLine consensus, while the over/under is 235.5 points. Before making any Spurs vs. Lakers picks, check out the NBA predictions and betting advice from the SportsLine Projection Model.

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The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model enters Week 12 of the 2025-26 NBA season on a sizzling 33-15 roll on top-rated NBA spread picks dating back to last season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen huge returns.

Now, the model has simulated Spurs vs. Lakers 10,000 times and just revealed its coveted NBA picks and betting predictions. You can head to SportsLine now to see the model's picks. Here are several NBA odds and NBA betting lines for Lakers vs. Spurs: 

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How to make Lakers vs. Spurs picks

After 10,000 simulations of Spurs vs. Lakers, SportsLine's model is going Under on the total (235.5 points). The total has not been reached in each of the last three Spurs games, while the Under has also hit in each of the Lakers last two contests. Not only that for San Antonio, but it has seen the Under go 9-2 over its last 11, and one can't forget this is the second night of a back-to-back for both teams. That's played a factor in Spurs games as the Under is 4-1 in such situations this season.

The Lakers haven't reached the total in each of their last five road games, and the team will be shorthanded on Wednesday with Reaves (calf) definitely out, while James may sit as well as he hasn't played a back-to-back this entire season. The teams are projected to combine for 232 points as the Under hits in well over 50% of simulations.

The model also says one side of the spread hits well over 50% of the time. You can head to SportsLine to see the model's NBA picks. 

So who wins Lakers vs. Spurs, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Spurs vs. Lakers spread to back, all from the model that has returned well over $10,000 on top-rated NBA picks, and find out.