Nuggets vs. Knicks odds, prediction, spread, time: 2026 NBA picks for Wednesday, February 4 from proven model

Teams trending in opposite directions meet when the Denver Nuggets face the New York Knicks in a key NBA matchup on Wednesday. Denver lost its second game in a row on Tuesday, falling 124-121 at Detroit, while New York won its seventh in a row with a 132-101 win at Washington. The Nuggets (33-18), who are second in the Northwest Division, are 19-8 on the road this season. The Knicks (32-18), who co-lead the Atlantic Division with Boston, are 20-6 on their home court. Aaron Gordon (hamstring) and Cameron Johnson (knee) remain out for Denver. Josh Hart (ankle) is questionable for New York.

Tipoff from Madison Square Garden in New York is set for 7 p.m. ET. New York is a 5.5-point favorite in the latest Nuggets vs. Knicks odds from DraftKings Sportsbook, while the over/under for total points scored is 226.5. Before making any Nuggets vs. Knicks picks, check out the NBA predictions and betting advice from the SportsLine Projection Model.

New users can target the DraftKings promo code, which offers $300 in bonus bets if your $5+ bet wins:

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model enters Week 16 of the 2025-26 NBA season on a sizzling 38-16 roll on top-rated NBA spread picks dating back to last season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen huge returns.   

Now, the model has simulated Nuggets vs. Knicks 10,000 times and just revealed its coveted NBA picks and betting predictions. You can head to SportsLine now to see the model's picks. Here are several NBA odds and NBA betting lines for Knicks vs. Nuggets:

New users can check out the latest bet365 bonus code to get $200 in bonus bets after placing a $5 bet:

How to make Nuggets vs. Knicks picks

After 10,000 simulations of Nuggets vs. Knicks, SportsLine's model is going Over on the total (226.5). The Over has hit in two of the last three head-to-head meetings. The Over has also hit in each of the last five Denver games, while it hit in the last New York game. 

The SportsLine model is projecting Denver's Nikola Jokic to score 24.8 points on average and be one of four Nuggets players to score 12.3 or more points. New York's Jalen Brunson, meanwhile, is projected to have 26.9 points as six Knicks players score 10.9 points or more.

It has also generated an against-the-spread pick that hits in nearly 60% in simulations. You can head to SportsLine to see the model's NBA picks. 

So who wins Nuggets vs. Knicks, and which side of the spread hits nearly 60% of the time? Visit SportsLine now to see which side of the Nuggets vs. Knicks spread to back, all from the model that has returned well over $10,000 on top-rated NBA picks, and find out.