Pacers vs. Celtics odds, prediction, time: 2026 NBA picks for Wednesday, January 21 from proven model

The Boston Celtics look to secure the season series when they battle the Indiana Pacers in an NBA Eastern Conference matchup on Wednesday night. Indiana is coming off a 113-104 loss at Philadelphia on Monday, while Boston dropped a 104-103 decision at Detroit that same day. The Pacers (10-34), who are fifth in the Central Division, are just 2-18 on the road this season. The Celtics (26-16), who lead the Atlantic Division, are 12-7 on their home floor. Indiana will be without Benedict Mathurin (thumb).

Tip-off from TD Garden in Boston is set for 7:30 p.m. ET. The Celtics lead the all-time series 112-88, and have won two of the three previous meetings this season. Boston is a 10.5-point favorite in the latest Pacers vs. Celtics odds from DraftKings Sportsbook, while the over/under for total points scored is 226.5. Before making any Celtics vs. Pacers picks, check out the NBA predictions and betting advice from the SportsLine Projection Model.

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The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model enters Week 14 of the 2025-26 NBA season on a sizzling 35-15 roll on top-rated NBA spread picks dating back to last season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen huge returns.   

Now, the model has simulated Pacers vs. Celtics 10,000 times and just revealed its coveted NBA picks and betting predictions. You can head to SportsLine now to see the model's picks. Here are several NBA odds and NBA betting lines for Celtics vs. Pacers:

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How to make Pacers vs. Celtics picks

SportsLine's model is going Over on the total (226.5 points). The total has gone Over in four of the last six head-to-head meetings. The Pacers are 5-5 against the spread in their last 10 games, while the Celtics are 6-4 ATS in their last 10. 

The SportsLine model is projecting Indiana's Pascal Siakam to score 22.1 points on average and be one of four Pacers players to score 10.3 or more points. Boston's Jaylen Brown, meanwhile, is projected to have 29.8 points as six Celtics players score 10 points or more.

It has also generated an against-the-spread pick that hits in well over 60% of simulations. You can head to SportsLine to see the model's NBA picks. 

So who wins Celtics vs. Pacers, and which side of the spread hits well over 60% of the time? Visit SportsLine now to see which side of the Pacers vs. Celtics spread to back, all from the model that has returned well over $10,000 on top-rated NBA picks, and find out.