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The New Orleans Pelicans will look to sweep the two-game season series with the Indiana Pacers when they meet in NBA action on Friday night. New Orleans is coming off a 116-113 win over Brooklyn on Wednesday, while Indiana dropped a 115-101 decision to Toronto that same night. The Pelicans (10-33), who are fifth in the Southwest Division, are 3-15 on the road this season. The Pacers (9-32), who are fifth in the Central Division, are 7-16 on their home court. Herbert Jones (ankle) and Jose Alvarado (oblique) will miss the game for New Orleans, while Bennedict Mathurin (thumb) and Isaiah Jackson (concussion) are out for Indiana.

Tioff from Gainbridge Fieldhouse in Indianapolis, is set for 7 p.m. ET. The Pacers lead the all-time series 30-22, but the teams have split each of the last four games. Indiana is a 3.5-point favorite in the latest Pelicans vs. Pacers odds from DraftKings Sportsbook, while the over/under for total points scored is 238.5. Before making any Pelicans vs. Pacers picks, check out the NBA predictions and betting advice from the SportsLine Projection Model.

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The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model enters Week 13 of the 2025-26 NBA season on a sizzling 34-15 roll on top-rated NBA spread picks dating back to last season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen huge returns.    

Now, the model has simulated Pelicans vs. Pacers 10,000 times and just revealed its coveted NBA picks and betting predictions. You can head to SportsLine now to see the model's picks. Here are several NBA odds and NBA betting lines for Pacers vs. Pelicans:

Pelicans vs. Pacers spread:    

Indiana -3.5 at DraftKings    

Pelicans vs. Pacers over/under:    

238.5 points

Pelicans vs. Pacers money line:    

New Orleans +135, Indiana -160

Pelicans vs. Pacers picks:    

See picks at SportsLine

Pelicans vs. Pacers streaming:

Fubo (Try for free)   

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How to make Pelicans vs. Pacers picks

SportsLine's model is going Over on the total (238.5 points). The total has gone Over in two of the last three Pelicans games. The SportsLine model is projecting New Orleans' Zion Williamson to score 21.7 points on average and be one of six Pelicans players to score 13.2 or more points. Indiana's Pascal Siakam, meanwhile, is projected to have 27.2 points as five Pacers players score 11.7 points or more. 

It has also generated an against-the-spread pick that hits well over 60% of the time. You can head to SportsLine to see the model's NBA picks

So who wins Pelicans vs. Pacers, and which side of the spread hits well over 60% of the time? Visit SportsLine now to see which side of the Pelicans vs. Pacers spread to back, all from the model that has returned well over $10,000 on top-rated NBA picks, and find out.