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The Washington Wizards take on the Detroit Pistons in an NBA Eastern Conference matchup on Thursday night. Washington is coming off a 132-101 loss to the New York Knicks on Tuesday, while Detroit downed the Denver Nuggets 124-121 that same night. The Wizards (13-36), who are 8-20 against Eastern Conference foes, are 4-19 on the road this season. The Pistons (37-12), the top seed in the East, are 20-5 on their home floor. Cade Cunningham (wrist) and Tobias Harris (hip) are questionable for Detroit.

Tip-off from Little Caesars Arena in Detroit is set for 7 p.m. ET. The Pistons lead the all-time series 162-144, including wins in four of the last five meetings. Detroit is a 15.5-point favorite in the latest Pistons vs. Wizards odds from DraftKings Sportsbook, while the over/under for total points scored is 226.5. Before making any Wizards vs. Pistons picks, check out the NBA predictions and betting advice from the SportsLine Projection Model.

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The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model enters Week 16 of the 2025-26 NBA season on a sizzling 38-16 roll on top-rated NBA spread picks dating back to last season. Anyone following its NBA betting advice at sportsbooks and on betting apps could have seen huge returns.   

Now, the model has simulated Wizards vs. Pistons 10,000 times and just revealed its coveted NBA picks and betting predictions. You can head to SportsLine now to see the model's picks. Here are several NBA odds and NBA betting lines for Pistons vs. Wizards:

Wizards vs. Pistons spread:    

Detroit -14.5 at DraftKings    

Wizards vs. Pistons over/under:    

226.5 points

Wizards vs. Pistons money line:    

Washington +590, Detroit -885

Wizards vs. Pistons picks:    

See picks at SportsLine

Wizards vs. Pistons streaming:

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How to make Pistons vs. Wizards picks

After 10,000 simulations of Wizards vs. Pistons, SportsLine's model is going Under on the total (226.5). The Under has hit in four of the last six head-to-head meetings. The Under has also hit in four of the last eight Washington games, while the Under has hit in six of the last 10 Detroit games. The Wizards are 4-2 against the spread in their last six games, while the Pistons are 6-4 ATS in their last 10.

The SportsLine model is projecting Washington's Alex Sarr to score 19 points on average and be one of four Wizards players to score 11.1 or more points. Detroit, meanwhile, could be shorthanded with Cunningham and Harris both questionable. Additionally, the team just traded away Jaden Ivey, while new acquisition, Kevin Huerter (trade pending) is also questionable. Thus, the model calls for 221 combined points as the Under hits in 59.8% of simulations.

It has also generated an against-the-spread pick that hits nearly 70% in simulations. You can head to SportsLine to see the model's NBA picks

So who wins Pistons vs. Wizards, and which side of the spread hits nearly 70% of the time? Visit SportsLine now to see which side of the Wizards vs. Pistons spread to back, all from the model that has returned well over $10,000 on top-rated NBA picks, and find out.