The Week 16 NFL odds are balanced between home and road teams, with eight of each being favored in the season's third-to-last regular season week. The two largest of the Week 16 NFL spreads are home teams Buffalo (-14 vs. New England) and Green Bay (-14 vs. New Orleans). Both are future playoff teams facing squads that are well out of contention, but those are two of the largest NFL spreads of the entire season. The most compelling game on the Week 16 Sunday NFL schedule might be two NFC East rivals, Washington and Philadelphia (-4, 46.5). The Eagles are 4-1 against the spread as road favorites, 9-5 against the number overall, and have covered the spread in four of their last five games. The latest Commanders vs. Eagles forecast is calling for sunny skies, temperatures in the 30s, and light winds. Can they sweep their division rivals to clinch a division title and come through for anyone backing them with their Week 16 NFL best bets? Before you make any Week 16 NFL picks, be sure to see the exact NFL score predictions from SportsLine expert Eric Cohen.
Cohen, a SportsLine NFL expert and host of the Friday "Early Edge NFL Props Show" on SportsLine's YouTube page, evaluated the entire Week 16 NFL slate and delivers NFL score predictions and NFL analysis for each matchup. After a 14-2 betting record in Week 15, he is now 123-53 (70%) since Week 4. Anyone who followed Cohen's NFL predictions has been profitable at their favorite sports betting sites and betting apps. You can only see Cohen's Week 16 NFL exact score predictions at SportsLine.
Top Week 16 NFL picks
After diving into all 16 games from the NFL's Week 16, Cohen is high on the Los Angeles Rams (-3, 46.5) to beat the New York Jets, 28-24, to keep their NFC West title hopes alive. After a 1-4 start, the Rams have won 7 of their last 9 games and sit tied for the NFC West lead with the Seahawks. A key to Los Angeles' success has been wide receiver, Puka Nacua. Since returning from injury, the Rams are 6-2 and Nacua is averaging more than 96 receiving yards per game in that span.
Facing a Jets team that is well out of it at 4-10, Los Angeles' defense might be the key to continuing the team's recent successful run. They held San Francisco to six points in Week 15, but might have a tougher challenge against a New York squad that has scored 21 or more points in six of their last seven games and just saw quarterback Aaron Rodgers throw for three touchdowns against the Jaguars. Cohen believes the Rams will handle the cross-country team well and continue to hold the lead atop the competitive NFC West Division. See his other Week 16 football score predictions at SportsLine.
How to make Week 16 NFL score predictions
In addition, Cohen is calling for multiple high-scoring games this week, including in both AFC North divisional battles. Nailing these results is key to making profitable Week 16 NFL picks. You can only see it at SportsLine.
Who wins every Week 16 NFL game, and which games are must bets for the over? Visit SportsLine now to get Eric Cohen's NFL Week 16 score predictions, all from the NFL expert who has gone 123-53 since Week 4, and find out.
How to bet on NFL games
Here are the top sportsbooks to bet on NFL games this week, along with the various NFL sportsbook promos they currently offer.
