Life in the NFL has been a major adjustment for No. 1 overall pick Caleb Williams, but the Chicago Bears are 1-1 and had the ball with a chance to win the game late against the Houston Texans in Week 2. On Sunday, the Bears will visit the Colts and Indianapolis will be without star defensive lineman DeForest Buckner. Can the Bears give Williams protection after he was pressured on 82% of drop-backs last week? The Colts are 1-point home favorites in the latest Week 3 NFL odds, one of seven games on the Week 3 NFL schedule with NFL spreads of a field goal or less.

Which Week 3 NFL lines should you be targeting as you put together your Week 3 NFL parlay picks? Before you make any Week 3 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2024 NFL season on an incredible 187-130 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 41-22 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.

Now, the model has scoured the Week 3 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 3 NFL picks at SportsLine.

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Top Week 3 NFL picks

After simulating every game 10,000 times, the model is high on the Seattle Seahawks (-4.5, 42) cover at home against the Miami Dolphins. Seattle is off to a 2-0 start in Mike Macdonald's first season at the helm after wins over the Broncos and Patriots, and now the Seahawks will have the luxury of playing at home against a backup quarterback in Week 3.

Tua Tagovailoa suffered yet another concussion in Week 2 and was placed on injured reserve earlier this week, meaning Skylar Thompson will start at quarterback for Miami. Thompson made two starts in 2022 and has averaged only 5.2 yards per attempt on 119 career passes entering Week 3. That's a big reason why the model has the Seahawks covering in nearly 60% of simulations. See which other NFL parlay picks to make here.  

How to make Week 3 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including a home underdog that covers the spread in well over 60% of simulations, defying oddsmakers everywhere. You can only see the model's NFL Week 3 best bets and parlay at SportsLine.  

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What are the model's top Week 3 NFL picks, and which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 3 NFL best bets from a model on an 187-130 run on top-rated picks, and find out.