There have been three rookie quarterbacks who have started in the NFL so far, and a fourth will make his debut on Sunday when the Patriots host the Texans. No. 3 overall pick Drake Maye will make his debut for New England as first-year head coach Jerod Mayo looks for a spark after a 1-4 start. However, the Texans are 4-1 and coming off a high-profile win over the Bills. They are favored by 6.5 in the Week 6 NFL odds. Meanwhile, the Bills will try to take advantage of an organization in strife on Monday Night Football when they visit the Jets less than a week after New York fired Robert Saleh.
Buffalo is a 2.5-point road favorite in the NFL betting odds, so should you add the Bills to your Week 6 NFL parlay picks? Before you make any Week 6 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 6 of the 2024 NFL season on an incredible 10-2 hot streak on top-rated NFL picks this year. Longer term, it is on a 191-131 roll on top-rated NFL picks that dates back to the 2017 season and a 45-23 roll on top-rated NFL picks since Week 7 of 2022.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is way up.
Now, the model has scoured the Week 6 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you'd be looking at a massive payout of around 25-1. You can only see the model's Week 6 NFL picks at SportsLine.
Top Week 6 NFL picks
After simulating every game 10,000 times, the model is high on the Green Bay Packers (-5.5, 47.5) to cover at home against the Arizona Cardinals. Franchise quarterback Jordan Love suffered a knee injury in Week 1 and Malik Willis held down the fort with a pair of victories in his absence. However, Love returned to action in Week 4 and earned his first win of the season as a starter over the Rams in Week 5.
Love averaged a season-high 8.6 yards per pass attempt in the win and running back Josh Jacobs scored his first touchdown of the season. The big-money free agent signing has averaged 95 scrimmage yards per game and figures to be a problem for a Cardinals run defense that ranks 28th. Arizona has allowed five runners to pile up at least 65 rushing yards in the last three weeks, a major reason why the model has the Packers covering in over 60% of simulations. See which other NFL parlay picks to make here.
How to make Week 6 NFL parlays
The model also jumped on four other NFL matchups where it says the line is way off, including two underdogs that win outright, defying oddsmakers everywhere. You can only see the model's NFL Week 6 best bets and parlay at SportsLine.
What are the model's top Week 6 NFL picks, and which NFL matchups should you target for an epic 25-1 payout? Visit SportsLine now to see the Week 6 NFL best bets from a model on an 191-131 run on top-rated picks, and find out.