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The 2026 NFL playoffs roll on with four more Wild Card Weekend matchups. The top seeds -- Seattle in the NFC and Denver in the AFC -- received byes and will await their Divisional Round opponents. On Wild Card Sunday, it's Bills (+1.5) vs. Jaguars, 49ers vs. Eagles (-6) and Chargers vs. Patriots (-3.5). 

The Texans (-3) will then face the Steelers on 'Monday Night Football' at Pittsburgh as the Steelers look for their first playoff win since 2017. Before locking in any Wild Card Weekend NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the 2026 NFL playoffs on a 53-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, the model has scoured the 2026 Wild Card Weekend NFL odds and locked in five confident NFL best bets for the remaining games. If you successfully parlay its picks, you'd be looking at a massive payout of over 25-1. You can only see the model's Wild Card Weekend NFL picks at SportsLine.

Top 2026 Wild Card Weekend NFL picks

After simulating every game 10,000 times, the model is going Over 44.5 in the Eagles vs. 49ers matchup on Sunday at 4:30 p.m. ET. The total has dropped two points in this game, and the weather is expected to be above freezing at kickoff, leading to decent conditions for the offenses to operate. 

 Bet Eagles vs. 49ers at DraftKings below, and see our 25-1 Wild Card Weekend NFL parlay at SportsLine.

The 49ers have trended to the Over this season as they are 10-7 to that side. They are also 6-3 to the Over on the road. Philly has largely trended Under, but has seen six of its 10 games go Over when the total was less than 45 total points, as is the case in this one. Prior to falling flat against the Seahawks, the Niners were hot on offense, averaging 42.3 points per game over the prior three contests.

The model projects that the teams combine for 48 points as the Over hits 54% of the time. See which other NFL parlay picks to make here.

How to make Wild Card Weekend NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including backing an underdog that it says will easily cover. You can only see the model's 2026 Wild Card Weekend NFL best bets and NFL parlay at SportsLine.

What are the model's top 2026 Wild Card Weekend NFL picks, and which NFL matchups should you target for an epic 25-1 payout? Visit SportsLine now to see the 2026 NFL Wild Card Weekend NFL best bets from a model on a 53-37 run on top-rated picks, and find out.