The San Francisco 49ers seek their third straight victory as they host NFC West rival, the Seattle Seahawks on Sunday afternoon. The 49ers (5-4) enter off a 23-20 last second road victory over the Buccaneers, while the Seahawks enter off a bye following a 26-20 overtime loss to the Rams. San Francisco won this matchup on the road in Week 6, 36-24. The Niners are 4-5 against the spread, while the Seahawks are 2-6-1 ATS in 2024. Edge rusher Nick Bosa (hip), tight end George Kittle (hamstring) and offensive tackle Trent Williams (ankle) are among the players listed as questionable for San Francisco.
Kickoff from the Levi's Stadium is set for 4:05 p.m. ET. San Francisco is a 6.5-point favorite in the latest 49ers vs. Seahawks odds via SportsLine consensus, while the over/under for total points is 48. Before making any Seahawks vs. 49ers picks, you need to see the NFL predictions and betting advice from the proven computer model at SportsLine.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 11 of the 2024 NFL season on an incredible 17-7 betting hot streak on top-rated NFL picks this year. Longer term, it is on a 197-136 roll on top-rated NFL picks that dates back to the 2017 season and a 51-29 roll on top-rated NFL picks since Week 7 of 2022.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following at sportsbooks and on betting apps has seen strong returns.
Now, the model has set its sights on Seahawks vs. 49ers and just locked in its picks and NFL Week 11 predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and betting lines for Niners vs. Seahawks:
- 49ers vs. Seahawks spread: 49ers -6.5
- 49ers vs. Seahawks over/under: 48 points
- 49ers vs. Seahawks money line: 49ers -299, Seahawks +239
- 49ers vs. Seahawks picks: See picks at SportsLine
- 49ers vs. Seahawks streaming: FuboTV (Try for free)
Why the Seahawks can cover
Will the return of star wide receiver DK Metcalf help turn around the Seahawks' fortunes? Metcalf (knee) missed two games before Seattle's bye week, both losses by the team and he'll immediately resume the role of the offense's top playmaker in Week 11. In seven games this season, Metcalf has 578 yards and three touchdowns on 35 receptions. Against the 49ers in Week 6, he only caught 3 of 11 targets for 48 yards, so more efficiency is necessary for the team to be successful in Week 11.
Quarterback Geno Smith has run hot and cold this season, as evidenced by his 363-yard, three-touchdown and three-interception performance against Los Angeles in Week 9. Smith has 2,560 yards passing (fourth most in the NFL) though he has only thrown for 11 touchdowns against 10 interceptions. In the two road games he's played in this season, running back Kenneth Walker III has scored five total touchdowns and will look to continue his strong play in the Bay Area. Walker has totaled 615 yards and seven scores in only seven games. See which team to pick here.
Why the 49ers can cover
The reigning NFL Offensive Player of the Year, Christian McCaffrey, made his 2024 season debut in Week 10, accounting for 39 yards rushing and 68 receiving, while surprisingly being held scoreless. He was only held scoreless three times during his remarkable 2023 season. In two games against Seattle last year, McCaffrey rushed for more than 100 yards each time and scored two touchdowns. He should play a pivotal role this week as an increase in playing time seems likely.
Quarterback Brock Purdy continues to play like one of the league's best, having passed for 2,454 yards and 12 touchdowns with three additional rushing scorss this season. Against Tampa Bay, Purdy was outstanding, throwing for 353 yards and two touchdowns in the close victory. The Seahawks' defense is in for an uphill battle against the 49ers weapons on Sunday afternoon. See which team to pick here.
How to make Seahawks vs. 49ers picks
The model has simulated Seattle vs. San Francisco 10,000 times and the results are in. It is leaning Over on the point total, and it also says one side of the spread hits nearly 60% of the time. You can only see the model's 49ers vs. Seahawks pick at SportsLine.
So who wins Seahawks vs. 49ers on Sunday, and which side of the spread hits nearly 60% of the time? Visit SportsLine right now to see which side of the Seattle vs. San Francisco spread you should be all over Sunday, all from the model on a 197-136 roll on its top-rated NFL picks, and find out.