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Sunday features the busiest day of Wild Card Weekend with a tripleheader, starting with the Jacksonville Jaguars hosting the Buffalo Bills at 1 p.m. ET, followed by the Philadelphia Eagles hosting the San Francisco 49ers at 4:30 p.m. ET, and concluding with the New England Patriots hosting the Los Angeles Chargers on Sunday Night Football. The two most surprising postseason teams out of the Sunday tripleheader are the Jaguars and Patriots, who both won their divisions to host on Wild Card Weekend. Partly due to that homefield advantage, the SportsLine model is backing the Jaguars on the money line at -108 odds, and the Patriots to cover as 3.5-point favorites as part of its best Sunday NFL parlay for Wild Card Weekend at DraftKings. The Jaguars have won eight straight games, entering the playoffs with the second-longest active winning streak, as a key reason why the model is including them in its Sunday Wild Card Weekend NFL best bets.

The model is also backing Over 44.5 total points scored for the 49ers vs. Eagles. Both teams are deep at skill position with Brock Purdy and Jalen Hurts orchestrating the offenses at quarterback, leading the model to project plenty of points and include this Over in its best Sunday NFL parlay at DraftKings.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the 2026 NFL playoffs on a 53-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Best Sunday NFL parlay for Wild Card Weekend at DraftKings (odds subject to change): 

  • Jaguars (-108) to defeat the Bills
  • 49ers vs. Eagles Over 44.5 points (-110)
  • Patriots (-3.5) vs. Chargers (-112)

This Sunday Wild Card Weekend NFL parlay at DraftKings would result in a payout of +595 (risk $100 to win $595).

Jaguars (-108) to defeat the Bills

The Jaguars roll into the playoffs on an eight-game winning streak, and they've won four straight games at home. Jacksonville went 7-2 at home this season, with its only two losses coming to the Rams and Seahawks, who are the two current betting favorites to win the Super Bowl at DraftKings. Meanwhile, Josh Allen clearly isn't at full health as he fights through a foot injury, and the Jaguars have the No. 8 scoring defense (19.8 ppg allowed) this season. Jacksonville is averaging 36.4 ppg over its last five games, and the model projects the Jaguars to win in 52% of simulations.

49ers vs. Eagles Over 44.5 points (-110)

Before last week's defensive showdown in a 13-3 loss to the Seahawks, the 49ers blew past this total in each of their last three games. The 49ers entered last week with at least 37 points scored in three straight games, while also allowing at least 24 points in each contest for high totals. Those three games had an average total of 72 points, with the 49ers' offense averaging 42.3 ppg over that span. The Eagles rested their starters last week, but they scored at least 29 points in two of their three prior games. With playmakers all over the field, including the 49ers' Christian McCaffrey, George Kittle and Jauan Jennings with Brock Purdy, and the Eagles' Saquon Barkley, A.J. Brown and DeVonta Smith with Jalen Hurts, the model projects the Over to hit in 52% of simulations. 

Patriots (-3.5) vs. Chargers (-112)

Yes, the Patriots have played an incredibly easy schedule this season, but you can only play the teams that are put in front of you, so that shouldn't be held against New England. The Patriots (14-3) largely took care of the teams they were expected to beat, but they also defeated the Bills in Buffalo on Sunday Night Football, proving they can knock off quality teams in front of a primetime audience. The Patriots went 6-3 at home this season with five of their six wins coming by at least four points, and quarterback Drake Maye is coming off an MVP-caliber season. Weather is often a factor in postseason football, and the Patriots are experienced playing in freezing Foxborough, which could be a significant advantage against a Los Angeles team traveling east for a Sunday Night Football contest. The model projects the Patriots to cover in 55% of simulations.