The Bills listed tight end Chris Gragg (knee), safety Da'Norris Searcy (hamstring), and Mike Williams as out for Sunday's game against the Packers.
Searcy, who left Week 14 against the Broncos and was unable to return, has 47 tackles and three interceptions this year in Buffalo.
Defensive end Jarius Wynn (knee) is listed as questionable while kicker Dan Carpenter (groin) and defensive tackle Stefan Charles (quad) are probable.