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Seahawks LT Russell Okung vs. Falcons DE John Abraham: Abraham is playing on a bad ankle that he hurt two weeks ago. But he will play, and he is key to the Atlanta pass rush. Okung has played at a Pro Bowl level, so I would imagine he would spend a lot of time single-blocking Abraham. Keep an eye on Abraham's push-off with the ankle issues.
49ers LT Joe Staley vs. Packers OLB Clay Matthews: In the first meeting, Matthews destroyed Staley. But Staley broke his nose early in that game, and it could have played a role. He has to be better against Matthews this week. He was overpowered at times in that game.
Texans G Ben Jones vs. Patriots DT Vince Wilfork: In the first meeting, Wilfork dominated Jones. He was a big reason the Texans didn't run it that well with Arian Foster. Jones has to be better. Or he will be replaced regularly with Brandon Brooks. Wilfork is also good at chasing down plays from the backside. Cutting him is key for Jones.
Texans S Danieal Manning vs. Patriots TE Rob Gronkowski: Gronkowski missed the first meeting between the teams. But he is back now and will be a tough matchup for the Texans. But having Manning at safety, a former corner, will help. I would expect to see Gronkowski doubled a lot, too.
Broncos LT Ryan Clady vs. Ravens DE Terrell Suggs: Clady did a really nice job on Suggs in the last meeting. He is playing for a new contract and really played well. Suggs missed the early part of the season while coming back from an Achilles tendon injury, but he is improving by the week. He has to get pressure on Peyton Manning.
Broncos CB Champ Bailey vs. Ravens WR Torrey Smith: The veteran Bailey remains one of the best cover players in the league. Smith is the deep speed for the Ravens, and he has to be able to stretch the field. Look for the Ravens to take a few shots against the man coverage of the Broncos.