jakobi-meyers-jaguars
Imagn Images

AFC South rivals square off in Week 17 of the 2025 NFL season when the Jacksonville Jaguars visit the Indianapolis Colts. The Jaguars are in the mix for the No. 1 seed in the AFC, while the Colts are set to miss the playoffs despite starting the season 8-2, thanks in large part to Daniel Jones' season-ending injury. The Jaguars won the first meeting between these teams, 36-19.

Kickoff from Lucas Oil Stadium is set for 1 p.m. ET. Jacksonville is a 6.5-point favorite in the latest Jaguars vs. Colts odds at DraftKings, and the total comes in at 48.5. Before making any Colts vs. Jaguars picks of your own, make sure to look at the top NFL picks from the SportsLine Projection Model, which simulates every NFL game 10,000 times.

Where to watch Jaguars vs. Colts on Sunday

When: Sunday, Dec. 28
Time: 1 p.m. ET
TV: FOX
Stream: Fubo  
Follow along: CBS Sports App

Jaguars vs. Colts betting preview

Odds: Jaguars -6.5, over/under 48.5

Jacksonville is thriving in Liam Coen's first season and has gone 10-5 ATS on the season. The Colts are 7-6-2 ATS on the season but have faltered of late since a lot of their covers came early in the season when there was doubt over Jones' abilities. Indianapolis is 8-7 to the Over while Jacksonville is 9-6 to the Over.

Jaguars vs. Colts SGP

  • Colts +6.5
  • Over 48.5
  • Jakobi Meyers anytime touchdown scorer

Bet it at DraftKings:

Model's Jaguars vs. Colts score prediction, picks

The SportsLine Projection Model has the Colts covering the 6.5-point spread in 55% of simulations and Indianapolis wins in 41% of simulations, offering value at +240 odds. The Over on 48.5 hits in 50% of simulations.

Jaguars vs. Colts score prediction: Jaguars 27, Colts 23

Want more Week 17 NFL picks?

You've seen the model's best bets for Jacksonville Jaguars vs. Indianapolis Colts. Now, get against the spread, total and money-line picks for every Week 17 NFL game here, all from the model that's simulated every game 10,000 times.