The Buffalo Bills (2-0) will host the Jacksonville Jaguars (0-2) in the first half of a Monday Night Football doubleheader. Each team has a streak on the line on MNF, as Jacksonville needs its first win, while the Bills are looking to stay undefeated. These two clubs have matched up 19 times in history, with Jacksonville owning a 10-9 lead. They last met on October 8, 2023, when the Jaguars beat the Bills, 25-20.
Kickoff from at Highmark Stadium in Buffalo, NY., is set for 7:30 p.m. ET. Buffalo is a 5.5-point favorite in the latest Jaguars vs. Bills odds via SportsLine consensus, while the over/under for total points scored is 45.5. Before locking in any Bills vs. Jaguars picks, make sure to check out the NFL predictions and betting advice from the SportsLine expert Mike Tierney.
A veteran sportswriter whose work appears periodically in the New York Times and Los Angeles Times, Mike Tierney has covered the NFL for decades and reported from seven Super Bowls. Mike is 154-124-9 in the NFL the past two seasons, returning $1,586 to $100 players. Tierney also has a strong read on the Jags. In fact, he is 41-18 (+2161) on his last 59 NFL picks in games involving Jacksonville. Anyone who has followed him is way up.
Now, Tierney has locked in on Jaguars vs. Bills and just revealed his coveted NFL picks and sports betting predictions. You can head to SportsLine now to see his picks. Here are several NFL odds and NFL betting lines on the spread, money line and over/under for Bills vs. Jaguars:
- Jaguars vs. Bills spread: Buffalo -5.5
- Jaguars vs. Bills over/under: 45.5 points
- Jaguars vs. Bills money line: Buffalo -250, Jacksonville +203
- BUF: Bills have hit the 2Q money line in 10 of their last 19 games
- JAX: Jaguars have covered the 1H spread in 13 of their last 21 games
- Jaguars vs. Bills picks: See picks at SportsLine
Why the Bills can cover
The Bills' offense is revamped this year, but they have a strong group of pass-catchers. Receiver Khalil Shakir is a sound route-runner who has plenty of body control to win on multiple levels. In two games, the Boise State product has eight catches for 96 yards and one touchdown. Shakir has logged 40-plus yards in consecutive games.
Receiver Keon Coleman is a physical playmaker. Coleman owns the verticality to rise above defenders to make tough grabs. The Florida State product has reeled in four catches for 51 yards. Running back James Cook is also a weapon as a pass-catcher. The Georgia product sneaks out of the backfield to give Buffalo a safety valve. He has four grabs for 49 yards. See who to back at SportsLine.
Why the Jaguars can cover
Quarterback Trevor Lawrence isn't off to the hottest start ,but he has the skillset to be effective in any contest. Lawrence has a strong throwing arm with the athleticism to gain yards with his legs. In his last outing, the Clemson product threw for 220 yards and rushed for 45. In 52 career games, Lawrence completed 63% of his passes for 12,152 yards and 59 passing touchdowns.
Running back Travis Etienne Jr. provides Jacksonville with an explosive playmaker in the backfield. Etienne Jr. has the vision to hit the open hole in a flash while using his speed to break away. Prior to this season, he has finished with 1,000-plus rushing yards in consecutive years. In two matchups so far this season, Etienne Jr. has 96 rushing yards, 21 receiving yards, and two scores. See who to back at SportsLine.
How to make Jaguars vs. Bills picks
Tierney has analyzed Bills vs. Jaguars from every possible angle and while we can tell you he's leaning Over the point total, he has also discovered a critical X-factor that has him jumping all over one side of the spread. Find out what it is at SportsLine.
So who wins Bills vs. Jaguars on Monday Night Football, and what critical x-factor makes one side hit hard? Visit SportsLine now to see which side of the Bills vs. Jaguars spread to back, all from the expert who is 41-18 on picks involving Jacksonville, and find out.