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Six of the 11 games being played on Sunday have NFL spreads of six points or greater, according to the latest Week 12 NFL odds from the SportsLine Consensus, which could signal heavy running back production. Larger underdogs include the Cowboys (vs. Commanders), Titans (vs. Texans), and Patriots (vs. Dolphins). Quarterbacks Cooper Rush, Will Levis and Drake Maye won't be expensive for NFL DFS lineups, so is there value in including them in cheaper NFL DFS stacks with players like Jalen Tolbert, Calvin Ridley or Demario Douglas? This will save money for some of the top options in the NFL DFS player pool. Before making any NFL DFS picks for Sunday or locking in NFL DFS lineups on sites like DraftKings and FanDuel, be sure to check out SportsLine's advanced NFL DFS Lineup Optimizer.

The DFS Optimizer uses info from the SportsLine Advanced-Data Projection Model and DFS Professional Millionaire Mike McClure to identify top DFS picks/plays for any slate on betting apps like DraftKings and FanDuel. It simulates every game 10,000 times to help DFS players optimize and build winning DraftKings and FanDuel lineups. Optimize, export, and enter lineups confidently with injury updates, floor and ceiling player projections, and Vegas lines and picks all with one winning tool for sports betting apps.

Now, SportsLine's NFL DFS Optimizer has turned its attention to Sunday's 2024 NFL Week 12 schedule and just locked in its top daily Fantasy football lineups. You can only see its optimal lineups at SportsLine.

Top NFL Week 12 DFS picks for Sunday

One of the Optimizer's top DFS value picks for Sunday is 49ers wide receiver Jauan Jennings ($5,600 on DraftKings and $6,700 on FanDuel). Jennings had 10 receptions for 91 yards and a touchdown last week after having seven receptions for 93 yards the week before. He had 11 targets in each contest as has taken on a primary role in the offense with Brandon Aiyuk (knee) out for the season.

Jennings has played more than 90% of snaps the last two weeks. Of the three games he has played at least 85% of snaps in, Jennings is averaging 9.3 receptions for 119.7 yards with four total touchdowns. The 27-year-old leads the 49ers in receiving yards despite only playing eight games and drawing more than six targets in just three of those eight. With Aiyuk out, expect the targets and production to continue on Sunday. See who else to pick here.

The Optimizer's NFL DFS strategy also includes rostering Cardinals running back James Conner ($6,500 on DraftKings and $7,700 on FanDuel). The 29-year-old running back is coming off the one thing nearly every eight-year NFL veteran loves -- rest. The Cardinals had their bye last week, so Conner could rest his legs after being one of the most relied-upon backs in the league this year. Conner is 11th in the NFL in carries as he's played at least 80% of snaps in two of Arizona's last four games.

Conner had 113 total yards in Week 10 against the Jets, including a 45-yard catch-and-run on the opening series. After his receiving touchdown was overturned on replay, Conner ran in the 1-yard score to still return an incredible opening drive for daily Fantasy football players. He has at least 110 total yards in three of his last four games heading into a matchup against the Seahawks, who have allowed the fifth-most rushing yards to running backs this season and are allowing 138.6 total rushing yards per game this year. You can see the rest of the Optimizer's NFL DFS picks here.

How to build Sunday Week 12 NFL DFS lineups

The NFL DFS Optimizer is also targeting multiple undervalued players who could explode for huge numbers on Sunday. Those players could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who they are, and the rest of the Optimizer's NFL DFS picks, at SportsLine

So what is the optimal NFL DFS lineup for Sunday, and which under-the-radar NFL DFS picks offer huge value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice and stacks, all from an NFL DFS Optimizer that simulates every game 10,000 times, and find out.