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The penultimate game of Wild Card Weekend comes on 'Sunday Night Football' as the New England Patriots host the Los Angeles Chargers at 8:15 p.m. ET. The Patriots are 3.5-point favorites at DraftKings Sportsbook, while the over/under is 45.5, matching the second highest total on the board for the first round of the 2026 NFL playoffs. The kickoff temperature is expected to hover around freezing, so that'll be a factor when crafting NFL DFS strategy for any showdown slates on sites like DraftKings or FanDuel.

Chargers running back Omarion Hampton (ankle) is active after missing Week 18 and being listed as questionable for 'SNF'. How should that impact your NFL DFS lineups, and what NFL DFS picks can give your salary-cap roster an edge? Before making any NFL daily Fantasy picks for Patriots vs. Chargers, be sure to check out the NFL DFS advice, strategy and stacks from SportsLine daily Fantasy expert Mike McClure.

You can also bet props like Hampton as an anytime TD scorer (+185) using the latest DraftKings promo code, which offers $300 in bonus bets if your bet wins:

McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings, including. In 2023, he finished tied for first in the DraftKings Millionaire Maker twice and the FanDuel Million once. Anyone who has followed him could be way up.

Now, McClure has turned his attention to the Wild Card 'Sunday Night Football' DFS slate and just locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine. 

Top NFL DFS picks for Patriots vs. Chargers

One of McClure's top NFL DFS picks for 'Sunday Night Football' is New England quarterback Drake Maye. He burst into the MVP conversation this season after completing 72% of passes for 4,394 yards, 31 touchdowns and just eight interceptions. His rushing production increased as well as he piled up 450 yards and four scores on the ground. Both defenses in this game have strong numbers against opposing quarterbacks, but McClure is confident in Maye's ability to still produce at a reasonable price. See who else to roster at SportsLine, and bet Maye to go Over 240.5 passing yards at DraftKings Sportsbook:

McClure is also building around Los Angeles receiver Ladd McConkey, who is going against a New England defense that gave up the sixth-most touchdowns to opposing receivers this season. His season-long numbers are down compared to last year, but he's still shown big-play ability recently, making a catch of at least 25 yards in each of his past two games. He's also scored six times in the past 12 games, showing that he has around a coin flip's chance to find the end zone in this playoff matchup. See more NFL DFS picks at SportsLine, and bet McConkey to go Over 3.5 receptions at DraftKings:

How to set Chargers vs. Patriots DFS lineups

McClure is targeting another undervalued player who could explode for huge numbers on 'Sunday Night Football'. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of McClure's NFL DFS picks, at SportsLine.

So who is Mike McClure including in his optimal NFL DFS lineups for 'Sunday Night Football', and which under-the-radar player offers huge value? Visit SportsLine now to see optimal NFL DFS picks, NFL DFS rankings, NFL DFS advice and NFL DFS stacks, all from a daily Fantasy expert with more than $2 million in winnings, and find out.