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No bye weeks and no games outside of the traditional primetime slots sets up a jumbo Week 15 NFL DFS main slate schedule with 13 games unfolding on Sunday afternoon. Matthew Stafford and Drake Maye are among the most expensive quarterbacks on this slate, but their matchups differ substantially with Stafford facing a Detroit squad that has given up the 28th most Fantasy points to opposing QBs, while Maye faces a Buffalo defense ranked No. 6 against opposing quarterbacks.

How should all that factor into your NFL DFS picks this week, and who are the sleepers in the NFL DFS player pool that can help differentiate your lineups? Before making any NFL DFS picks for Sunday or locking in NFL DFS lineups on sites like DraftKings and FanDuel, be sure to check out SportsLine's advanced NFL DFS lineup optimizer.

You can also bet props like Drake Maye going Over 234.5 passing yards using the latest DraftKings promo code, which offers $200 in bonus bets if your bet wins:

The DFS Optimizer uses info from the SportsLine Advanced-Data Projection Model and DFS Professional Millionaire Mike McClure to identify top DFS picks/plays for any slate on betting apps like DraftKings and FanDuel. It simulates every game 10,000 times to help DFS players optimize and build winning DraftKings and FanDuel lineups. Optimize, export, and enter lineups confidently with injury updates, floor and ceiling player projections, and Vegas lines and picks all with one winning tool.

Now, SportsLine's NFL DFS Optimizer has turned its attention to Sunday's 2025 NFL Week 15 schedule and just locked in its top daily Fantasy football lineups. You can only see its optimal lineups at SportsLine.

Top NFL Week 15 DFS picks for Sunday

One of the optimizer's top DFS value picks for Sunday is Commanders quarterback Marcus Mariota at $5,000 on DraftKings and $6,700 on FanDuel. Jayden Daniels (elbow) has been ruled out, clearing the way for Mariota, the veteran backup, to appear in his 10th game this season. He threw for 294 yards and two touchdowns while rushing for 55 against a tough Denver defense in his last start. He get a more favorable matchup this time, facing the Giants and a defense that has given up the third most Fantasy points to opposing quarterbacks. See who else to pick here.

You can also bet on Mariota to go Over 206.5 total passing yards at DraftKings:

The optimizer's NFL DFS strategy also includes building around Ravens running back Derrick Henry at $8,400 on FanDuel and $7,300 on DraftKings. Henry has scored four touchdowns in the past four weeks, and he's generally known as a back who dominates late in the season in cold-weather games. The Ravens take on the Bengals and the worst rushing defense in the league on Sunday. With kickoff temperature expected to be around 11 degrees, this is the type of game Henry can thrive in. You can see the rest of the optimizer's NFL DFS picks here.

Bet Henry to go Over 88.5 rushing yards at DraftKings:

How to build Sunday Week 15 NFL DFS lineups

The NFL DFS Optimizer is also targeting multiple undervalued players who could explode for huge numbers on Sunday. Those players could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who they are, and the rest of the optimizer's NFL DFS picks, at SportsLine. 

So what is the optimal NFL DFS lineup for Sunday, and which under-the-radar NFL DFS picks offer huge value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice and stacks, all from an NFL DFS optimizer that simulates every game 10,000 times, and find out.