Self-learning AI generates NFL picks, score predictions for every 2026 divisional round matchup

The 2026 NFL divisional round schedule features two games on Saturday, and two on Sunday. Saturday's intriguing matchup will pit NFC West rivals when Bock Purdy and the San Francisco 49ers battle Sam Darnold and the Seattle Seahawks. The Seahawks are favored by 7 (over/under 44.5 points) at DraftKings Sportsbook in what's the largest of the divisional round NFL lines. Darnold (oblique) is listed as questionable, but told reporters that he's planning to play. 

Other divisional round NFL spreads include Texans vs. Patriots (-3, 40.5) and Rams (-4.5, 48.5) vs. Bears, both on Sunday. The smallest spread in the divisional round is Bills vs. Broncos (-1.5, 45.5) on Saturday, and those odds flipped after Buffalo opened as 1.5-point favorites. Before making any 2026 NFL divisional round picks or NFL score predictions, you need to see the NFL against the spread, over/under and money line predictions powered by the self-learning SportsLine AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data and then quantitatively evaluating the strength of the opponent's defense by assigning a numeric value out of 100 called a matchup score. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine's AI PickBot has hit more than 2,000 4.5- and 5-star prop picks since the start of the 2023 season. 

For 2026 NFL divisional round NFL betting, SportsLine AI has evaluated the NFL odds and provided NFL betting picks for all four games. You can only see the AI predictions for the 2026 NFL divisional round schedule here.

Top 2026 NFL divisional round AI picks

After analyzing every game in the divisional round, SportsLine AI says the Texans (+3) cover in a tight, low-scoring matchup against the Patriots on Sunday at 3 p.m. ET.

Houston was one of the most impressive teams on Wild Card Weekend, demolishing the Steelers 30-6 on Monday in an elite defensive effort. The offense still has some question marks coming into this matchup, but Houston's defense should be well-equipped to keep this game competitive. 

SportsLine AI is projecting the Pats to win 15.9-13.5 and says the Texans covering, which returns +100, is a B-rated pick. See its other 2026 NFL divisional round football predictions and football picks at SportsLine, and bet the Patriots at DraftKings here:

How to make 2026 NFL divisional round picks

In addition, the AI PickBot has generated three highly-coveted A+ picks for the 2026 NFL divisional round. You need to see the AI's NFL picks before making any 2026 Wild Card Weekend NFL bets of your own. You can only see them at SportsLine.

Who wins and covers each 2026 NFL divisional round game, and which A+ picks should you target now? Visit SportsLine now to see the top NFL picks against the spread, over-under and on the money line, all from the SportsLine AI that has nailed more than 2,000 highly-rated picks since the start of the 2023 season.