The Patriots have listed the following players as inactive for Sunday's game against the Bills: Dan Connolly, Sebastian Vollmer, Julian Edelman, Rob Gronkowski, Jonas Gray, Dont'a Hightower and Brandon Browner.
Gray missed Friday's practice while dealing with an ankle injury and was ruled out for the game.
Browner (groin) and Hightower (shoulder) were both questionable coming into the contest.
The Patriots have also clinched a first-round bye and home-field advantage throughout the playoffs.