Rams vs. 49ers odds, prediction, line, time: 2024 Thursday Night Football picks by NFL model on 25-11 roll

SportsLine's model simulated the San Francisco 49ers vs. Los Angeles Rams on Thursday Night Football 10,000 times and revealed its NFL best bets

By CBS Sports Staff

Dec 12, 2024 at 9:44 am ET • 3 min read

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The Los Angeles Rams and San Francisco 49ers will meet in a key NFC West matchup on Thursday Night Football. Los Angeles, which beat San Francisco, 27-24, in Week 3, will try to sweep the season series with the 49ers for the first time since 2018. The Rams (7-6), second in the NFC West, are coming off a 44-42 win over the Buffalo Bills last Sunday. The 49ers (6-7), tied for third in the division with the Arizona Cardinals, downed the Chicago Bears, 38-13, last week.

Kickoff from Levi's Stadium in Santa Clara, Calif., is set for 8:15 p.m. ET. The 49ers are three-point favorites in the latest Rams vs. 49ers odds, while the over-under for total points scored is 49. The 49ers are -150 money-line favorites, while the Rams are +126 underdogs. Before making any Rams vs. 49ers picks, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model, as well as everything else that SportsLine has to help you crush your Thursday Night Football picks.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 15 of the 2024 NFL season on an incredible 25-11 betting hot streak on top-rated NFL picks this year. Longer term, it is on a 205-139 roll on top-rated NFL picks that dates back to the 2017 season and a 59-32 roll on top-rated NFL picks since Week 7 of 2022.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following at sportsbooks and on betting apps has seen strong returns.

In addition to the model picks for this game, you can get AI props, Vegas expert picks, DFS Optimizer lineups, and everything else you need to crush your Thursday Night Football bets. Go to SportsLine now to see it all.

Now, the model has set its sights on Rams vs. 49ers and just locked in its NFL picks and NFL predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and NFL betting lines for Niners vs. Rams:

Rams vs. 49ers spread: 49ers -3
Rams vs. 49ers over/under: 49 points
Rams vs. 49ers money line: 49ers -150, Rams +126
LAR: Rams are 5-5 against the spread in their last 10 games
SF: 49ers are 4-6 ATS in their last 10 games
Rams vs. 49ers picks: See picks at SportsLine

Top Rams vs. 49ers predictions

For Rams vs. 49ers on Thursday Night Football, the SportsLine model is going Over the total. The Over has also hit in the last four Rams vs. 49ers matchups, including both games last season. The Over has hit in three of the last four meetings played at San Francisco. Defensively, both teams are in the bottom half of the league with San Francisco allowing 23.7 points per game, while Los Angeles allows 25.5.

Both offenses were clicking on Sunday, combining to score 82 points in their wins over the Bills and Bears. San Francisco quarterback Brock Purdy was on fire against Chicago, completing 20 of 25 passes for 325 yards and two touchdowns. Los Angeles quarterback Matthew Stafford completed 23 of 30 passes (76.7%) for 320 yards and two touchdowns against Buffalo.

In two of the last three meetings between the Rams and 49ers, they have combined for 51 or more points. In the Week 3 matchup, Purdy completed 22 of 30 passes for 292 yards and three touchdowns. Meanwhile, Rams running back Kyren Williams had a big game, rushing 24 times for 89 yards and two touchdowns. He also caught two passes for 27 yards and a score. See which side to pick here.