The Los Angeles Rams and San Francisco 49ers will meet in a key NFC West matchup on Thursday Night Football. Los Angeles, which beat San Francisco, 27-24, in Week 3, will try to sweep the season series with the 49ers for the first time since 2018. The Rams (7-6), second in the NFC West, are coming off a 44-42 win over the Buffalo Bills last Sunday. The 49ers (6-7), tied for third in the division with the Arizona Cardinals, downed the Chicago Bears, 38-13, last week.
Kickoff from Levi's Stadium in Santa Clara, Calif., is set for 8:15 p.m. ET. The 49ers are 2.5-point favorites in the latest Rams vs. 49ers odds, while the over-under for total points scored is 49. The 49ers are -142 money-line favorites, while the Rams are +120 underdogs. Before making any Rams vs. 49ers picks, be sure to see the NFL predictions and betting advice from SportsLine's proven computer model, as well as everything else that SportsLine has to help you crush your Thursday Night Football picks.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 15 of the 2024 NFL season on an incredible 25-11 betting hot streak on top-rated NFL picks this year. Longer term, it is on a 205-139 roll on top-rated NFL picks that dates back to the 2017 season and a 59-32 roll on top-rated NFL picks since Week 7 of 2022.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following at sportsbooks and on betting apps has seen strong returns.
In addition to the model picks for this game, you can get AI props, Vegas expert picks, DFS Optimizer lineups, and everything else you need to crush your Thursday Night Football bets. Go to SportsLine now to see it all.
Now, the model has set its sights on Rams vs. 49ers and just locked in its NFL picks and NFL predictions. You can head to SportsLine now to see the model's picks. Here are several NFL odds and NFL betting lines for Niners vs. Rams:
- Rams vs. 49ers spread: 49ers -2.5
- Rams vs. 49ers over/under: 49 points
- Rams vs. 49ers money line: 49ers -142, Rams +120
- LAR: Rams are 5-5 against the spread in their last 10 games
- SF: 49ers are 4-6 ATS in their last 10 games
- Rams vs. 49ers picks: See picks at SportsLine
Top Rams vs. 49ers predictions
For Rams vs. 49ers on Thursday Night Football, the SportsLine model is going Over the total, projecting 49 total points. The Over has also hit in each of the last four Rams vs. 49ers matchups, including both games last season. The Over has hit in three of the last four meetings played at San Francisco. Defensively, both teams are in the bottom half of the league with San Francisco allowing 23.7 points per game, while Los Angeles allows 25.5.
Both offenses were clicking on Sunday, combining to score 82 points in their wins over the Bills and Bears. San Francisco quarterback Brock Purdy was on fire against Chicago, completing 20 of 25 passes for 325 yards and two touchdowns. Los Angeles quarterback Matthew Stafford completed 23 of 30 passes (76.7%) for 320 yards and two touchdowns against Buffalo.
In two of the last three meetings between the Rams and 49ers, they have combined for 51 or more points. In the Week 3 matchup, Purdy completed 22 of 30 passes for 292 yards and three touchdowns. Meanwhile, Rams running back Kyren Williams had a big game, rushing 24 times for 89 yards and two touchdowns. He also caught two passes for 27 yards and a score. See which side to pick here.
How to make Rams vs. 49ers picks
In addition to going Over, It also says one side of the spread hits nearly 60% of simulations. You can only get the NFL model's picks at SportsLine.
So who wins Rams vs. 49ers on Thursday Night Football, and which side of the spread cashes in nearly 60% of simulations? Visit SportsLine now to see which side of the Rams vs. 49ers spread to jump on, all from the advanced model that is up well over $7,000 on its NFL picks, and find out, and don't forget to see AI props, Vegas expert picks, DFS Optimizer lineups, and all the other tools to crush your TNF picks at SportsLine.
