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Two NFC division leaders square off in Week 17 action when the Seattle Seahawks visit the Carolina Panthers. Each team is coming off a massive divisional win, with Seattle upsetting the Los Angeles Rams in a thrilling Thursday Night Football affair to move to 12-3 and in the driver's seat for both the NFC West title and the No. 1 seed in the conference, while the Panthers beat the Tampa Bay Buccaneers to enter Week 17 with a slim lead in the division. Those teams meet again in Week 18 in a game that may very well be a win-or-go-home situation for both sides.

Kickoff from Bank of America Stadium is set for 1 p.m. ET on CBS and Paramount+. The Seahawks are 7.5-point road favorites per the latest Seahawks vs. Panthers odds from DraftKings, while the over/under for total points scored is 42.5. Before making any Panthers vs. Seahawks picks of your own, make sure to look at the top NFL picks from the SportsLine Projection Model, which simulates every NFL game 10,000 times. 

Where to watch Seahawks vs. Panthers on Sunday

When: Sunday, Dec. 28
Time: 1 p.m. ET
TV: CBS
Stream: Paramount+  
Follow along: CBS Sports App

Seahawks vs. Panthers betting preview

Odds: Seahawks -7.5, Over/Under 42.5

The Seahawks and Panthers have both over-performed in comparison to preseason expectations, and that's especially true when it comes to their records against the spread. Seattle is 10-5 ATS this year while Carolina is 9-6. The Seahawks have seen nine of their 15 games go Over the total, while the Panthers are 7-8 to the Over this year.

Seahawks vs. Panthers SGP

  • Panthers +7.5
  • Over 42.5
  • Zach Charbonnet anytime touchdown

Bet it at DraftKings:

Model's Seahawks vs. Panthers score prediction, picks

The model projects another Seahawks win in their quest to win the NFC West and take home the No. 1 seed, but it does think Carolina will continue to be competitive. The model has the Panthers covering 52% of the time and winning outright 34% of the time. The Over hits in nearly 60% of simulations. 

Seahawks vs. Panthers score prediction: Seahawks 27, Panthers 20

Want more Week 17 NFL picks?

You've seen the model's best bets for Seattle Seahawks vs. Carolina Panthers. Now, get against the spread, total and money-line picks for every Week 17 NFL game here, all from the model that's simulated every game 10,000 times.