The Week 12 NFL schedule is looking like another must-see slate and the NFC West will take center stage with a trio of high-profile NFL matchups that could have a major impact on the division and NFL playoff picture. The Cardinals are division leaders at 6-4, but they'll take on the Seahawks (5-5) with first place on the line. Meanwhile, the 49ers (5-5) will visit the Packers (7-3) and the Rams (5-5) will host the Eagles on Sunday Night Football. Arizona is favored by one point in the latest Week 12 NFL odds, a four-point swing from the opener, while the 49ers are three-point underdogs and could be without quarterback Brock Purdy (shoulder). Los Angeles is a 3-point home underdog in the NFL betting spreads. How should you handle those NFL games and optimize what to bet on NFL in Week 12? Before you make any Week 12 NFL picks and Week 12 NFL score predictions, you need to see the NFL against the spread, over-under, and money line predictions powered by the self-learning SportsLine AI.
Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data and then quantitatively evaluating the strength of the opponent's defense by assigning a numeric value out of 100 called a matchup score.
Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.
In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine's AI PickBot has hit a whopping 2,029 4.5- and 5-star prop picks since the start of last season. Anyone who has followed it is way up at their best sports betting app and favorite betting sites.
For Week 12 NFL betting, the AI PickBot has evaluated the NFL odds and provided NFL betting picks for all 13 games. You can only see the AI predictions for the Week 12 NFL schedule here.
Top Week 12 NFL AI picks
After analyzing every game in Week 12, the AI PickBot says the Rams cover comfortably as three-point home underdogs against the Eagles on Sunday Night Football in a game with an over-under of 49. Matthew Stafford threw for 295 yards and four touchdowns in a 28-22 win over the Patriots last week and the Rams have now won four of five to get back to .500.
He has now thrown for 1,165 yards and 10 touchdowns with only three interceptions in the four games since Cooper Kupp and Puka Nacua returned to the lineup. Meanwhile, the Eagles are coming off back-to-back wins over division rivals and now have two tough road matchups in a row with the Rams and Ravens.
With a game-and-a-half lead in the NFC East, the AI PickBot is expecting a let-off game from the Eagles and rates the Rams cover as an A+ pick and also predicts a 26-20 win on average. See its other Week 12 football predictions and football picks at SportsLine.
How to make Week 12 NFL picks
In addition, the AI PickBot has generated eight highly-coveted A+ picks for Week 12. You need to see the AI PickBot's NFL picks before making any Week 12 NFL bets of your own. You can only see them at SportsLine.
Who wins and covers each Week 12 NFL game, and which A+ picks should you target now? Visit SportsLine now to see the top NFL picks against the spread, over-under, and on money line, all from the brand-new SportsLine AI PickBot that has nailed 2,029 top-rated picks since the start of last season.