Fresh off a blowout win over the Rams, the Cardinals will host the Lions in Week 3 with a chance to be a team to be taken seriously in the NFC. Kyler Murray had a perfect passer rating last week and rookie wide receiver silenced early critics with four catches for 130 yards and two touchdowns. Can the Cardinals win as three-point underdogs in the latest Week 3 NFL odds or will Detroit cover one of the slimmest NFL betting lines of the week? The over/under for that contest (51.5) is the highest of any game on the Week 3 NFL schedule. How should you treat that game as you make your Week 3 NFL score predictions or place your Week 3 NFL bets? Before you make any Week 3 NFL picks, you need to see the NFL against the spread, over-under, and money line predictions powered by SportsLine AI.
Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data and then quantitatively evaluating the strength of the opponent's defense by assigning a numeric value out of 100 called a matchup score.
Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.
In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. Last season, SportsLine's AI PickBot hit a whopping 1,674 4.5- and 5-star prop picks. Anyone who has followed it is way up.
For Week 3, the AI PickBot has evaluated the NFL odds and provided NFL betting predictions for all 16 games. You can only see the AI predictions for the Week 3 NFL schedule here.
Top Week 3 NFL AI picks
After analyzing every game in Week 3, the AI PickBot says the Rams cover as 6.5-point home underdogs against the 49ers. After a surprising 10-win season that got them back into the playoffs, the Rams are off to a disappointing 0-2 start after an overtime loss to the Lions and a blowout loss against the Cardinals. However, both matchups were on the road and Los Angeles has been better at home recently.
The Rams have won five of six at SoFi Stadium and are 7-3 against the spread overall in their last 10 games. They covered in both of their head-to-head matchups with the 49ers last year, winning outright as 5.5-point underdogs in Week 18 last season. Both teams are dealing with key losses, with Puka Nacua and Cooper Kupp out for the Rams, while Deebo Samuel and Christian McCaffrey are unavailable for the 49ers. Ultimately, the AI PickBot says Los Angeles keeps it within the spread on Sunday. See its other Week 3 football predictions and football picks at SportsLine.
How to make Week 3 NFL picks
In addition, the AI PickBot has generated five other A-rated picks for Week 3. You need to see the AI PickBot's picks before making any Week 3 NFL bets of your own. You can only see them at SportsLine.
Who wins and covers each Week 3 NFL game, and which A-rated picks should you target? Visit SportsLine now to see the top NFL picks against the spread, over-under, and on money line, all from the brand-new SportsLine AI PickBot that nailed 1,674 top-rated picks last season.