After nail-biting victories over the Ravens and Bengals to open the season, the Chiefs are off to a 2-0 start as they try to become the first franchise to three-peat as Super Bowl champions. Patrick Mahomes and the Chiefs will take on Kirk Cousins and the Falcons on Sunday Night Football in one of the marquee matchups on the Week 3 NFL schedule and Atlanta is coming off a thrilling come-from-behind win of its own. Can Cousins deliver in primetime and defy the NFL odds, or will a short week against the two-time defending world champions be too tough of a test?

It's another loaded NFL slate and having advanced NFL betting data to inform your Week 3 NFL score predictions and NFL picks could help give you an edge as you make NFL ATS picks, NFL ML picks, and NFL OU picks. Before you make any Week 3 NFL picks, you need to see the NFL against the spread, over-under, and money line predictions powered by SportsLine AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data and then quantitatively evaluating the strength of the opponent's defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

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In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. Last season, SportsLine's AI PickBot hit a whopping 1,674 4.5- and 5-star prop picks. Anyone who has followed it is way up.

For Week 3, the AI PickBot has evaluated the NFL odds and provided NFL betting predictions for all 16 games. You can only see the AI predictions for the Week 3 NFL schedule here.

Top Week 3 NFL AI picks

After analyzing every game in Week 3, the AI PickBot says the Rams cover as 7.5-point home underdogs against the 49ers. he NFL is always a war of attrition and both of these two NFC West opponents are in a spot of bother entering Week 3. The 49ers were already without Christian McCaffrey (calf) and now Deebo Samuel has a calf injury of his own that is expected to cost him multiple weeks.

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Meanwhile, the Rams are down Puka Nacua (knee), Cooper Kupp (ankle) and a handful of offensive lineman. Ultimately, the AI PickBot is playing the trends here and backing the home team. Los Angeles has covered in two of three against San Francisco and has covered in seven of its last nine games while the 49ers are just 1-5 ATS over their last six. Underdogs are also 16-14-2 against the spread overall in the NFL this season and the AI PickBot is rating the Rams to cover as an A-graded pick. See its other Week 2 football predictions and football picks at SportsLine.

How to make Week 3 NFL picks

In addition, the AI PickBot has generated five other A-rated picks for Week 3. You need to see the AI PickBot's picks before making any Week 3 NFL bets of your own. You can only see it at SportsLine.

Who wins and covers each Week 3 NFL game, and which A-rated picks should you target?  Visit SportsLine now to see the top NFL picks against the spread, over-under, and on money line, all from the brand-new SportsLine AI PickBot that nailed 1,674 top-rated picks last season.

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