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The Week 4 NFL schedule features three winless teams, which means time is running out for the Bengals, Jaguars and Titans to keep their playoff hopes alive. Cincinnati entered the season as a Super Bowl contender, but it has lost its first three games. The Bengals were favored by more than a touchdown in two of those contests and are 4.5-point road favorites at Carolina on Sunday in the Week 4 NFL odds. The Panthers are coming off their first win of the season, so which team should you back with your Week 4 NFL best bets and NFL predictions?

Meanwhile, there are five unbeaten teams looking to stay perfect this weekend, including Seattle, which travels to Detroit as a 4-point road underdog in the Week 4 NFL spreads. The Seahawks cruised to a blowout win over the Dolphins last week, while the Lions beat the Cardinals on the road. So before you make any Week 4 NFL picks, you need to see the NFL against the spread, over-under, and money line predictions powered by the self-learning SportsLine AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data and then quantitatively evaluating the strength of the opponent's defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. Last season, SportsLine's AI PickBot hit a whopping 1,674 4.5- and 5-star prop picks. Anyone who has followed it is way up.

For Week 4 NFL betting, the AI PickBot has evaluated the NFL odds and provided NFL betting predictions for all 16 games. You can only see the AI predictions for the Week 4 NFL schedule here.

Top Week 4 NFL AI picks

After analyzing every game in Week 4, the AI PickBot says the Jaguars cover as seven-point road underdogs against the Texans. This is certainly a buy-low spot on Jacksonville, as it has lost each of its first three games and is coming off a 47-10 loss at Buffalo. However, the Bills have looked like the best team in the NFL so far this season, and the Jaguars were within five points in their losses to the Dolphins and Browns.

Houston is coming off a horrendous performance at Minnesota last week, getting crushed in a 34-7 final as a 1.5-point road favorite. The Texans have only covered the spread once in their last six September games, and quarterback C.J. Stroud threw two interceptions and was sacked four times against the Vikings. Jacksonville picked up a road win at Houston last season, and the AI PickBot has the Jaguars losing this game by just two points. See its other Week 4 football predictions and football picks at SportsLine.

How to make Week 4 NFL picks

In addition, the AI PickBot has generated 11 other A-rated picks for Week 4. You need to see the AI PickBot's picks before making any Week 4 NFL bets of your own. You can only see them at SportsLine.

Who wins and covers each Week 4 NFL game, and which A-rated picks should you target?  Visit SportsLine now to see the top NFL picks against the spread, over-under, and on money line, all from the brand-new SportsLine AI PickBot that nailed 1,674 top-rated picks last season.