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USATSI

Two teams having opposite starts to their season will square off when the Tampa Bay Buccaneers host the Denver Broncos on Sunday. Baker Mayfield and the Buccaneers have been opportunistic two weeks into the 2024 season and are 2-0 after beating the Detroit Lions as 7.5-point underdogs. The same can't be said about the 0-2 Broncos, as rookie quarterback Bo Nix battles to meet high expectations. The Buccaneers opened as 3-point favorites in the Week 3 NFL lookahead lines, but that line has increased to 6.5 in the latest NFL odds. Should you include the Buccaneers in your Week 3 NFL picks and ride the hot hand? Before you make any Week 3 NFL picks, you need to see the NFL against the spread, over-under, and money line predictions powered by SportsLine AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data and then quantitatively evaluating the strength of the opponent's defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. Last season, SportsLine's AI PickBot hit a whopping 1,674 4.5- and 5-star prop picks. Anyone who has followed it is way up.

For Week 3, the AI PickBot has evaluated the NFL odds and provided NFL betting predictions for all 16 games. You can only see the AI predictions for the Week 3 NFL schedule here.

Top Week 3 NFL AI picks

After analyzing every game in Week 3, the AI PickBot says the Rams cover as 6.5-point home underdogs against the 49ers. Both teams are missing key players heading into this NorCal-SoCal matchup, which puts them on their heels offensively. San Francisco will be without stars Christian McCaffrey (calf) and Deebo Samuel (calf), while the Rams continue to miss Puka Nacua (knee) and Cooper Kupp (ankle).

While both sides are at a disadvantage, the PickBot likes the Rams to cover the spread at home. San Francisco has won three of the last four meetings with L.A., but is 1-5 ATS over its last six. The 49ers could still win a close game, but the AI PickBot has the Rams to cover as an A-grade pick. See its other Week 3 football predictions and football picks at SportsLine.

How to make Week 3 NFL picks

In addition, the AI PickBot has generated five other A-rated picks for Week 3. You need to see the AI PickBot's picks before making any Week 3 NFL bets of your own. You can only see them at SportsLine.

Who wins and covers each Week 3 NFL game, and which A-rated picks should you target?  Visit SportsLine now to see the top NFL picks against the spread, over-under, and on money line, all from the brand-new SportsLine AI PickBot that nailed 1,674 top-rated picks last season.