There have been 30 games decided by eight points or fewer this season, the most through three weeks in NFL history. Close games have been the norm, and close NFL spreads are also frequent. Just two contests in Week 4, Jets vs. Broncos (+7.5) and 49ers vs. Patriots (+10.5), have Week 4 NFL lines of more than a touchdown. Nine games have a team favored by a field goal or less in the NFL odds, including divisional battles like Saints vs. Falcons (-2.5) and Vikings vs. Packers (-2.5). No team has a worse against the spread record since 2023 than Atlanta (6-14), but New Orleans has covered in just two of its last nine September games.
As for Packers vs. Vikings, each team has covered four times in their last eight meetings. These teams aren't making Week 4 NFL score predictions easy for you, so it would be wise to seek unbiased NFL betting advice. Before you make any Week 4 NFL picks, you need to see the NFL against the spread, over-under, and money line predictions powered by the self-learning SportsLine AI.
Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data and then quantitatively evaluating the strength of the opponent's defense by assigning a numeric value out of 100 called a matchup score.
Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see an A-rating on an over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.
In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. Last season, SportsLine's AI PickBot hit a whopping 1,674 4.5- and 5-star prop picks. Anyone who has followed it is way up.
For Week 4 NFL betting, the AI PickBot has evaluated the NFL odds and provided NFL betting predictions for all 16 games. You can only see the AI predictions for the Week 4 NFL schedule here.
Top Week 4 NFL AI picks
After analyzing every game in Week 4, the AI PickBot says the Jaguars cover as 6-point road underdogs against the Texans. Underdogs of 6-plus points are 11-1-1 against the spread this season, including the Bears covering as 6.5-point underdogs versus Houston in Week 2. That game was part of a four-game against-the-spread losing streak for the Texans, the second-longest streak in the league.
The Texans are coming off a 27-point defeat to Minnesota, their largest of the DeMeco Ryans and C.J. Stroud era. Stroud tied a career-high with two interceptions, and Houston is a team that constantly shoots itself in the foot, as just two squads have more penalties than the Texans. Those penalties either shorten offensive drives or keep opponents' drives going, and Jacksonville can take advantage since it ranks third in the league with 5.4 yards per carry. The AI PickBot has this game being decided by less than a field goal, which would allow Jacksonville to cover as a 6-point underdog. See its other Week 4 football predictions and football picks at SportsLine.
How to make Week 4 NFL picks
In addition, the AI PickBot has generated 11 other A-rated picks for Week 4. You need to see the AI PickBot's picks before making any Week 4 NFL bets of your own. You can only see them at SportsLine.
Who wins and covers each Week 4 NFL game, and which A-rated picks should you target? Visit SportsLine now to see the top NFL picks against the spread, over-under, and on money line, all from the brand-new SportsLine AI PickBot that nailed 1,674 top-rated picks last season.