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The Divisional Round of the 2026 NFL playoffs begins on Saturday with a doubleheader featuring the No. 1 seeds in each conference, providing two top matchups to use the current DraftKings promo code, which gives new users $300 in bonus bets if your first $5 bet wins. The Denver Broncos host the Buffalo Bills at 4:30 p.m. ET, followed by the Seattle Seahawks hosting the San Francisco 49ers at 8 p.m. ET. SportsLine expert Eric Cohen says the rested Broncos will come out and defend their homefield, picking the Broncos on the money line as part of SportsLine's Saturday best bets at DraftKings. In the second game, SportsLine expert Micah Roberts is backing the 49ers to keep pace with Seattle, backing San Francisco as a 7.5-point underdog.

The SportsLine projection model's top pick from the Saturday doubleheader is the Seahawks vs. 49ers game to go Over 45.5 points. They went Under this total in their two regular-season matchups, but both teams feature top-10 offenses that average a combined 54 points per game. Claim the latest DraftKings promo code, where new users get $300 in bonus bets if your first $5 bet wins

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The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the divisional round of the 2026 NFL playoffs on a 53-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Saturday best bets at DraftKings Sportsbook

  • Broncos (-120) vs. Bills 
  • 49ers (+7) vs. Seahawks
  • Over 45.5 in Seahawks vs. 49ers (-102)

Combining the three picks into a Saturday parlay at DraftKings would result in a payout of +585 (risk $100 to win $585, odds subject to change). Bet it at DraftKings here:

Broncos (-120) vs. Bills

"But Buffalo is SO banged up and now is facing one of the league's best defenses on the road," SportsLine expert Eric Cohen said. "The Bills whacked the Broncos last season, but Denver is improved in 2025-26 and Buffalo is worse. While I think this one will be extremely close, I lean the home team in another NFL playoff thriller. Broncos 24, Bills 21." Back the Broncos at DraftKings Sportsbook, where new users get $300 in bonus bets if your first $5 bet wins:

49ers (+7) vs. Seahawks (-105)

"Here's how I see it: The 49ers defense bends but doesn't break, and Brock Purdy makes the winning toss when the game matters, while Sam Darnold gets pinned for the loss," SportsLine expert Micah Roberts said. "The 49ers have the momentum from winning in Philadelphia last week and will keep it going against the team they just lost to that cost them a bye and the number one seed. The extra work and beating the Eagles did the 49ers some good. The 7.5-point spread is crazy, but give me all those points and give me the over as well, as that's the only way the 49ers can win this game." Back San Francisco at DraftKings Sportsbook, where new users get $300 in bonus bets if your first $5 bet wins:

Over 45.5 in Seahawks vs. 49ers (-102)

The Seahawks have the No. 2 scoring offense in the NFL, averaging 28.4 points per game with Sam Darnold continuing to prove his naysayers wrong. Darnold was fifth in the NFL in passing yards with 4,048 yards for his second straight 4,000-yard season. The Seahawks have a top running back tandem in Kenneth Walker III and Zach Charbonnet, along with Jaxon-Smith Njigba at receiver, who led the NFL with 1,793 receiving yards this season. Meanwhile, the 49ers' Brock Purdy has played like one of the top quarterbacks in the NFL in recent weeks, despite seemingly a new injury popping up in the offense weekly. But having Christian McCaffrey healthy in the backfield certainly helps create opportunities. Seven of the last eight 49ers' games hit the Over, and the Over is 12-5 in Seahawks contests this season. The model projects these trends to continue, with the Over hitting in 59% of simulations. Back the Over at DraftKings Sportsbook, where new users get $300 in bonus bets if your first $5 bet wins:

Want more NFL picks for Saturday?

You've seen some of the model's Saturday best bets. Now, get against the spread, total and money-line picks for all games, including NFL, NBA, college basketball, college football, NHL and more, all from the model that's simulated every game 10,000 times.