Week 18 NFL odds, lines, best bets, predictions: Computer model backing Packers and Titans

All of your Week 18 NFL picks will come on divisional contests as the league moved to this scheduling format a few years ago. Many of these matchups carry meaning for playoff seeding such as Panthers vs. Buccaneers (-3) and Seahawks vs. 49ers (+2.5) on Saturday, plus Broncos vs. Chargers (+13.5) and Ravens vs. Steelers (+3.5) on Sunday. Then there are games to make Week 18 NFL predictions on where one team is fighting for seeding while the other has already been eliminated from postseason contention. Some of these include Texans vs. Colts (+10.5) and Patriots vs. Dolphins (+11.5).

Motivation and incentive shouldn't be overlooked with your NFL best bets and when scouring the latest Week 18 NFL odds. The largest of the NFL spreads has Jacksonville as 13.5-point favorites over the Titans as the Jags could still land the No. 2 seed in the AFC. Meanwhile, one of the slimmest lines has the Bears favored by 3 points over Detroit as Chicago can clinch the No. 2 seed with a win. All of the updated Week 18 NFL lines are listed below, and SportsLine's advanced computer model has all the NFL betting advice and NFL predictions you need to make the best Week 18 NFL picks now.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 18 on a 53-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

Now, it has turned its attention to the latest Week 18 NFL odds and NFL betting lines and locked in betting picks for every NFL matchup. Head here to see every pick. 

Top Week 18 NFL predictions

We can tell you one of the model's strongest Week 18 NFL picks is that the Packers (+9.5, 36.5) cover at Minnesota on Sunday at 1 p.m. ET. Green Bay is locked into the No. 7 seed and will rest some starters, including a banged-up Jordan Love, but it should still have enough to stay within single digits versus an imbalanced Vikings team. Minnesota had 3 passing yards in its Christmas win over Detroit, which is the fewest by any team in a win in 19 years. The Vikings rank 29th in total offense, 30th in turnover differential and dead last in giveaways. Also, since Matt LaFleur became coach in 2019, Green Bay owns the NFL's third best spread record (19-10) as a road underdog. The model has Green Bay prevailing versus the spread nearly 70% of the time. See which other teams to pick here, and bet the Packers using the DraftKings promo code, which offers $200 in bonus bets if your bet wins right here:

Another one of its Week 18 NFL predictions: the Titans (-13.5, 47.5) cover versus the Jaguars in a Sunday kickoff at 1 p.m. ET. The Jags have won seven straight, can wrap up the division with a Week 18 win, and have a shot at the AFC's No. 1 seed if they get some help. This line keeps rising, however, and the Titans have shown enough in recent weeks to believe that this game will be more competitive than that line indicates. Tennessee is 2-2 straight up in its last four and are 5-3 against the spread in the last eight as Cam Ward continues to develop. SportsLine's model predicts that Jacksonville still wins by double digits, but it is Tennessee that covers well over 50% of the time. See which other teams to pick here, and bet the Titans to cover at DraftKings:

How to make Week 18 NFL picks

The model has also made the call on who wins and covers in every other game on the Week 18 NFL schedule and just revealed six teams projected to win by double-digits, potentially giving you a huge payday by playing the alternate lines. You can only get every pick for every game at SportsLine.

So what Week 18 NFL picks can you make with confidence, and which six picks should you lock in now? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $7,000, and find out.

Week 18 NFL betting odds, lines, live spreads, scores

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