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The Dallas Cowboys have the opportunity to start their season 2-0, so many fans and bettors will be deciding whether to include "America's Team" in their Week 2 NFL picks. Dak Prescott and company are confident after making quick work of Deshaun Watson and the Cleveland Browns in a 33-17 road win last Sunday. Week 2 won't be a cake walk, however, with the incoming New Orleans Saints coming off a decisive 47-10 win against the Carolina Panthers. These NFC opponents have traded off wins in recent years, although they haven't faced each other since a 27-17 Cowboys win in 2021. They are now six-point favorites to repeat that success in the Week 2 NFL odds. Before you make any Week 2 NFL picks or NFL parlays, be sure to see what SportsLine senior analyst Larry Hartstein has to say.

A former lead writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed working for Pro Football Focus. Hartstein tied for 52nd place (out of 1,598 entries) in the 2022 Westgate Las Vegas SuperContest, going 53-34-3 ATS. His weekly Vegas contest selections form the basis of his NFL best bets column, which is 81-49-2 (62.3%, +26.85 units) since its inception in 2022. He went 2-1 last week. Anyone who has followed him is way up.

For Week 2, Hartstein has locked in three confident best bets. If you successfully parlay his picks, you're looking at a payout of almost 6-1. You can only see Hartstein's Week 2 NFL picks at SportsLine.

Top Week 2 NFL picks

We can tell you Hartstein loves the Seahawks (-3) to cover against the Patriots. New England should be a confident bunch heading into their first home game of the season after upsetting Joe Burrow and the Cincinnati Bengals 16-10 in Week 1. Gillette Stadium hasn't been particularly kind to the Pats in recent history, however, as they have lost each of their last four home games and failed to cover the spread each time.

It doesn't help the Patriots' case that the Seahawks were good at covering the spread on the road last season, including in back-to-back games at Dallas and San Francisco. Seattle has also defeated New England in three of their last four meetings, so it's no surprise Hartstein is backing the Seahawks as the 3-point favorites. See which other NFL parlay picks to make here.

How to make Week 2 NFL parlays

Hartstein also jumped on two other NFL matchups, including backing one underdog who lost last week to "make adjustments" and grind out a strong Week 2 victory. You can only see Hartstein's Week 2 NFL best bets and parlay at SportsLine

What are Hartstein's top Week 2 NFL picks, and which other NFL matchups should you target for a strong 6-1 payout? Visit SportsLine now to see the Week 2 NFL best bets from the Vegas expert who is up 26.85 units on NFL ATS picks since 2022, and find out.