Week 1 NFL picks, predictions for Kalshi, Polymarket, Underdog: Bears-Panthers, Vikings-Packers markets

The Week 1 NFL schedule has arrived, and football fans will be treated to several must-see matchups for NFL predictions. One of those matchups includes an NFC North battle between the Green Bay Packers and Minnesota Vikings. The Vikings have won six of the past 10 meetings with Green Bay, including three of the past four. Quarterback Kyler Murray is set to make his first start for Minnesota after going 38-48-1 across 87 starts from 2019 to 2025 with the Arizona Cardinals. Kalshi, one of the largest NFL prediction markets, prices the Vikings at $0.53 per share, while Green Bay is trading at $0.47 per share.

All of the updated Week 1 NFL prediction market prices are listed below, and SportsLine's advanced computer model has all the NFL trading advice and NFL predictions you need to make the best Week 1 NFL picks now. Trade $25 and get up to a $500 bonus here with the Kalshi promo code CBSSPORTS:

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 1 on a 47-32 run on top-rated picks dating back to 2024. Anybody following its picks on NFL prediction markets and prediction market apps could have seen strong returns. Now, it has turned its attention to the latest Week 1 NFL prediction market prices and locked in predictions for every NFL matchup. Trade on the NFL here with the Polymarket promo code CBSSPORTS and get a $50 bonus after a $10 deposit:

Week 1 NFL predictions

Bears vs. Panthers preview 

Two teams that won their respective divisions are set to square off when the Carolina Panthers host the Chicago Bears in Week 1. The Bears are coming off a season in which they finished 11-6 under their first-year head coach Ben Johnson. Quarterback Caleb Williams played well in his first season under Johnson, finishing with 3,942 passing yards, 27 touchdowns and seven interceptions. Williams finished the year throwing two or more touchdowns in eight of his final nine contests, which includes two playoff games. 

Meanwhile, the Panthers topped the NFC South despite posting an 8-9 record. Panthers QB Bryce Young is coming off his best season as a professional, throwing for 3,011 yards and 23 touchdowns. Wide receiver Tetairoa McMillan was extremely effective for the Panthers in his rookie campaign, hauling in 70 receptions for 1,014 yards and seven scores. 

The SportsLine Projection Model has Chicago winning this matchup on the road by a score of 27-23. Kalshi prices the Bears at $0.58 per share to win, while the Panthers are trading at $0.42 per share to win. Claim the latest Kalshi promo code CBSSPORTS when you sign up for Kalshi here:

Vikings vs. Packers preview

Two bitter rivals will collide when the Minnesota Vikings host the Green Bay Packers for an NFC North clash at 4:25 p.m. ET. Minnesota has had the upper hand over its rivals in recent years, winning three of the past four meetings with Green Bay. The Vikings are coming off a disappointing 9-8 campaign, which included a 4-4 record. Minnesota's offense averaged just 275 yards per game last season, which is why the Vikings signed former No. 1 overall pick Kyler Murray this offseason. 

The Packers finished the 2025 campaign with a 9-7-1 record, losing to the Bears in the NFL Wild Card round. Head coach Matt LaFleur will look to lean on running back Josh Jacobs, who racked up 13 rushing touchdowns in 2025. Jacobs has now scored 12 or more rushing touchdowns in three of his past four seasons, but SportsLine's model is projecting Minnesota's defense to hold Jacobs to just 3.4 yards per carry on Sunday. 

The SportsLine Projection Model is calling for the Vikings to walk away with a 22-20 victory at home over Green Bay. Minnesota to win is trading at $0.53 per share, while the Packers are trading at $0.47 per share to beat the Vikings. Claim the latest Underdog Predict promo code here and register with the Underdog promo code CBS:

Week 1 NFL prediction market prices