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For the second year in a row, the Iowa Hawkeyes will face the Colorado Buffaloes in the Sweet 16 of the NCAA Women's Tournament. Last year, Colorado had a narrow lead at halftime, but Caitlin Clark led a third-quarter surge that put Iowa in front for good. What will be in store this time around? 

Clark and Co. survived a serious scare from West Virginia in the second round earlier this week, while Colorado went into Manhattan and stunned Kansas State to advance. Clark believes that she and the Hawkeyes will have plenty of support on Saturday in Albany, New York.

"When you get to go on the road, it kind of takes you back to see how many Iowa fans there are across the country, and that's kind of been the biggest thing for us all year," Clark told CBS Sports. "No matter where we've been able to go, whether it was on the East Coast, whether it was Nebraska, anywhere, we had great crowds." 

All the action is set for Saturday afternoon in Albany, New York, with a trip to the Elite Eight on the line. Here's what you need to know.

How to watch (1) Iowa vs. (5) Colorado

Date: Saturday, March 30 | Time: 3:30 p.m. ET
Location: MVP Arena -- Albany, New York
TV: ABC | Live stream: fubo (Try for free)

Iowa vs. Colorado: Key storyline

The big matchup in this game is Clark against Jaylyn Sherrod, Colorado's fifth-year guard and three-time All-Pac-12 Defensive Team honoree. Sherrod is a terrific on-ball defender with the capability to bother Clark, but got into foul trouble in last year's meeting. As a result, she spent little time actually guarding Clark, who went off for 31 points on 50% shooting in that game. 

Colorado is a strong defensive team, and IT will certainly look to follow West Virginia's blue print by being physical and aggressive on the perimeter. Can Sherrod stay out of foul trouble and lead the line? And how will Clark respond after shooting poorly in the first two games of the tournament? 

The answer to those questions will determine who advances to the Elite Eight and who sees their season come to an end. 

Who wins Colorado vs. Iowa, and which Caitlin Clark prop bet is a must-back? Visit SportsLine now to see which side of the Iowa vs. Colorado spread hits, all from the expert who's up 371 units since the start of the 2021-22 season, and find out.