The Week 10 NFL schedule features 14 games, starting on Thursday Night Football when the New York Giants host the Washington Commanders. According to the latest NFL odds, the Giants are favored by 2.5 points, while the over/under for total points scored is 41. The Jaguars are the largest favorites at 9.5 points against the Titans, according to the Week 10 NFL spreads. Cowboys vs. 49ers carries the highest total at 55.5 points. Bet on every NFL game with the latest DraftKings promo code, where new users get $200 in bonus bets plus 3 free months of NBA League Pass after making a $5 wager:
Below you'll find the NFL betting odds for every Week 10 matchup. You can find the SportsLine Projection Model's NFL betting advice for Week 10 here. Trade $25+ at Kalshi using the best Kalshi promo code CBSSPORTS55 and get a $55 bonus:
** Odds provided by DraftKings are subject to change **
Thursday, November 12
Washington Commanders vs. New York Giants
Spread: Giants -2.5
Moneyline: Giants (-135), Commanders (+110)
Total: 41
Sunday, November 15
New England Patriots vs. Detroit Lions
Spread: Lions -3
Moneyline: Lions (-148), Patriots (+124)
Total: 51.5
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Kansas City Chiefs vs. Atlanta Falcons
Spread: Chiefs -3.5
Moneyline: Chiefs (-175), Falcons (+145)
Total: 45.5
Houston Texans vs. Cleveland Browns
Spread: Texans -4.5
Moneyline: Texans (-192), Browns (+160)
Total: 39.5
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Minnesota Vikings vs. Green Bay Packers
Spread: Packers -3.5
Moneyline: Packers (-180), Vikings (+150)
Total: 42.5
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Jacksonville Jaguars vs. Tennessee Titans
Spread: Jaguars -9.5
Moneyline: Jaguars (-485), Titans (+370)
Total: 47.5
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Miami Dolphins vs. Indianapolis Colts
Spread: Colts -3.5
Moneyline: Colts (-192), Dolphins (+170)
Total: 38.5
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Carolina Panthers vs. New Orleans Saints
Spread: Saints -1.5
Moneyline: Saints (-108), Panthers (-112)
Total: 47.5
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Buffalo Bills vs. New York Jets
Spread: Bills -7.5
Moneyline: Bills (-470), Jets (+360)
Total: 51.5
Seattle Seahawks vs. Las Vegas Raiders
Spread: Seahawks -3.5
Moneyline: Seahawks (-170), Raiders (+142)
Total: 43.5
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Los Angeles Rams vs. Arizona Cardinals
Spread: Rams -9.5
Moneyline: Rams (-429), Cardinals (+360)
Total: 39.5
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San Francisco 49ers vs. Dallas Cowboys
Spread: 49ers -3.5
Moneyline: 49ers (-218), Cowboys (+180)
Total: 55.5
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Pittsburgh Steelers vs. Cincinnati Bengals
Spread: Bengals -3.5
Moneyline: Bengals (-180), Steelers (+150)
Total: 47.5
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Monday, November 16
Los Angeles Chargers vs. Baltimore Ravens
Spread: Ravens -4.5
Moneyline: Ravens (-205), Chargers (+170)
Total: 38.5
Week 10 byes: Bears, Broncos, Eagles and Buccaneers.
