The Week 10 college football schedule features a blockbuster Big Ten matchup between No. 3 Penn State (7-0) and No. 4 Ohio State (6-1) on Saturday afternoon. Ohio State lost to Oregon in mid-October before narrowly escaping with a win over Nebraska as a massive favorite last week. The Buckeyes are 3-point road favorites against the Nittany Lions in the Week 10 college football odds, while the over/under is 47.5. Using Week 10 college football score predictions can help identify the best college football bets on the spread, total and money line for that game and others. 

Top-ranked Oregon will be on the road this week when it travels to Michigan (3:30 p.m. ET, CBS) as a 14.5-point favorite in the Week 10 college football spreads, with the over/under at 45. The Wolverines are 19-1 in their last 20 games at home, but should you back the Wolverines to keep it close against Oregon when you make your Week 10 college football exact score predictions? Before you make any Week 10 college football picks, make sure you see the latest college football predictions from SportsLine's proven model.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and it is a sizzling 16-7 on all top-rated picks over the past five weeks of this season. Anyone following at sportsbooks and on betting apps has seen strong returns.

Now, the model has simulated every Week 10 game 10,000 times. You can only see the model's Week 10 college football exact score predictions at SportsLine.

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Top Week 10 college football picks

After diving into every game on the Week 10 college football schedule, the model is backing the No. 2 Georgia Bulldogs (-14.5, 52.5) to beat the Florida Gators, 41-20, at EverBank Stadium in Jacksonville, covering the spread in a game that goes over the total. Georgia had several sluggish performances at the end of September, narrowly beating Kentucky before losing to then-No. 4 Alabama. The Bulldogs have responded with a three-game winning streak, including their 30-15 win at then-No. 1 Texas two weeks ago. 

Senior quarterback Carson Beck has 1,993 passing yards and 15 touchdowns, while junior running back Trevor Etienne has 422 rushing yards and seven touchdowns. Florida is coming off a blowout win over Kentucky, but it has also suffered double-digit losses to Miami and Texas A&M this season. The Bulldogs have won the last three meetings between these teams by more than 20 points, and SportsLine's model expects them to follow that trend on Saturday. See the model's other Week 10 college football score predictions here.

How to make Week 10 college football score predictions

The model has also released score predictions for every FBS matchup in Week 10, and it's calling for seven underdogs to win outright. You can only get every score prediction for every game at SportsLine.

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Who wins each Week 10 college football game, and which underdogs win outright in Week 10? Visit SportsLine now to get the model's college football Week 10 score predictions, all from the model that has generated well over $2,000 on its top-rated college football picks, and find out.