The Pittsburgh Panthers (7-2) will take aim at a signature win on Saturday when they host the No. 20 Clemson Tigers (7-2). Pitt opened the season with seven consecutive victories before suffering back-to-back losses in its past two games. Clemson, meanwhile, bounced back from its loss against Louisville with a 24-14 win over Virginia Tech. These teams have split their last four head-to-head meetings. Pitt quarterback Eli Holstein (head) is reportedly out.
Kickoff from Acrisure Stadium in Pittsburgh is set for noon ET. The Tigers are 12.5-point favorites according to the latest Clemson vs. Pittsburgh odds via SportsLine consensus, while the over/under for total points scored is 49.5. Before locking in any Pitt vs. Clemson picks, you'll want to see the college football predictions from the advanced computer model at SportsLine.
The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and it is a strong 18-12 on all top-rated picks over the past seven weeks of this season. Anyone following at sportsbooks and on betting apps has seen strong returns.
Now, the model has set its sights on Clemson vs. Pittsburgh. You can head to SportsLine now to see its picks. Here are several college football betting lines for Pitt vs. Clemson:
- Clemson vs. Pitt spread: Clemson -12.5
- Clemson vs. Pitt over/under: 49.5 points
- Clemson vs. Pitt money line: Clemson -500, Pittsburgh +368
- Clemson vs. Pitt betting trends: Clemson is 5-4 ATS, Pitt is 5-3 ATS
- Clemson vs. Pitt picks: See picks at SportsLine
- Clemson vs. Pitt streaming: FuboTV (Try for free)
Why Clemson can cover
The Tigers enter Saturday's showdown with a 7-1 record over their past eight games. Dabo Swinney's squad has had success this season thanks to its efficient offense, which is averaging 37.7 points per game. That's good enough for 14th in the nation.
Clemson is led by veteran quarterback Cade Klubnik. The junior signal caller has thrown for 2,275 yards, 24 touchdowns and four interceptions this season. He's thrown three or more touchdown passes in six of his last eight outings, including last week's win over the Hokies. Defensively, Clemson is giving up 22.44 points per game. The Tigers held Virginia Tech to only 40 rushing yards and an average of 3.9 yards per play last week. See which team to pick here.
Why Pitt can cover
The Panthers opened the season with seven straight wins before losing their last two games. Pitt is one of the most efficient passing teams in the nation, averaging 277.1 passing yards per game, which ranks 22nd in college football. Senior Konata Mumpfield is Pitt's leading receiver with 35 receptions for 560 yards and three touchdowns. He's averaging 16.0 yards per reception and is one of five players who've caught at least three touchdown passes.
The Panthers can also change the game on defense. Pitt has scored four defensive touchdowns in 2024, tied for the third-most in the nation. In last week's loss to Virginia, the defense recorded three sacks and forced two interceptions. See which team to pick here.
How to make Pitt vs. Clemson picks
The model has simulated Clemson vs. Pitt 10,000 times and the results are in. The model is leaning Over the total, and it's also generated a point-spread pick that is hitting in nearly 60% of simulations. You can only see the pick at SportsLine.
So who wins Clemson vs. Pittsburgh, and which side of the spread hits nearly 60% of the time? Visit SportsLine now to see which side of the spread to jump on, all from the advanced computer model that's up well over $2,000 on its top-rated college football spread picks since its inception, and find out.
