College football odds, picks, betting lines, top predictions for Week 10, 2024: Proven model loves Duke, SMU

SportsLine's advanced computer model has revealed its 2024 Week 10 college football picks

By CBS Sports Staff

Nov 2, 2024 at 7:24 am ET • 3 min read

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No. 1 Oregon confirmed its spot atop the polls with a 38-9 win over then-No. 20 Illinois last week, and it will try to remain unbeaten when it travels to Michigan (3:30 p.m. ET, CBS) on Saturday during the Week 10 college football schedule. The Ducks have won five of their last six games by at least 21 points, with their only close call coming in a win over then-No. 2 Ohio State. They are 14.5-point road favorites against Michigan in the Week 10 college football odds, despite being just 3-point favorites in the look-ahead lines earlier this season. Should you back the Ducks with your Week 10 college football bets?

The biggest game on the schedule this weekend will take place in University Park, where No. 3 Penn State is a 3-point home underdog against No. 4 Ohio State in a Big Ten showdown. The over/under in that game is 47.5. Other Week 10 college football spreads to monitor include No. 2 Georgia (-14.5) vs. Florida, No. 13 Indiana (-7.5) at Michigan State, and No. 11 Clemson (-10.5) vs. Louisville. Before locking in any Week 10 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine's proven model.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and it is a sizzling 16-7 on all top-rated picks over the past five weeks of this season. Anyone following at sportsbooks and on betting apps has seen strong returns.

Now, it has turned its attention to the latest college football odds and Week 10 college football betting lines. Head here to see every pick.

Top college football predictions for Week 10

One of the college picks the model is high on during Week 10: Duke (+21) easily stays within the spread at No. 5 Miami in a noon ET matchup on Saturday. Duke has only lost one game by double digits this season, which came in a 24-14 loss at Georgia Tech at the beginning of October. The Blue Devils bounced back with a win over Florida State before losing to then-No. 22 SMU in overtime last week.

They were 11.5-point underdogs against the Mustangs, but they had a chance to win the game on a 2-point conversion attempt on the final play. Miami has struggled as a heavy favorite over the past month, winning three straight games by seven points or less prior to its win over lifeless Florida State last week. The model has the Blue Devils staying within two scores on Saturday, and they are covering in well over 60% of simulations. See the rest of its Week 10 college football picks here.

Another prediction: No. 20 SMU (-7) extends its five-game winning streak against No. 18 Pittsburgh in an 8 p.m. ET kickoff on Saturday. The Mustangs are returning home following a successful three-game road trip that included wins over then-No. 22 Louisville, Stanford and Duke. Their only loss this season came in an 18-15 thriller against BYU in early September, but the Cougars are currently a top-10 team with an 8-0 record.

The Mustangs are averaging 443.5 yards and 39.1 points per game, led by sophomore quarterback Kevin Jennings. He has completed 64.3% of his passes for 1,594 yards and 10 touchdowns while rushing for 321 yards and three scores. The model has Jennings finishing with more than 300 total yards and nearly three touchdowns on Saturday, helping his team cover the spread well over 60% of the time. See picks for every other game in Week 10 here.

How to make college football picks for Week 10

The model has also made the call on who wins and covers in every FBS matchup in Week 10, and it's calling for seven underdogs to win outright. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence, and which seven underdogs win outright in Week 10? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned well over $2,000 in profit since its inception, and find out.